Association of maternal biliary disease with hepatopancreatobiliary morbidity in offspring.

IF 2.6 3区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-10-06 DOI:10.1002/jpn3.70219

Nathalie Auger, Angela Magri, Sarit Kang-Auger, Gabrielle Jutras, Jessica Healy-Profitós, Marianne Bilodeau-Bertrand, Gabriel Côté-Corriveau

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引用次数: 0

Abstract

Objectives: Maternal biliary disease is common, but the link with offspring hepatopancreatobiliary disease has not been studied. We assessed the association between maternal biliary disease and pediatric hepatopancreatobiliary morbidity.

Methods: We conducted a retrospective cohort study of 1,271,864 children born between 2006 and 2022 in Quebec, Canada. The exposure was maternal biliary disease. Offspring outcomes included congenital hepatopancreatobiliary anomalies, inborn errors of metabolism, and hepatopancreatobiliary morbidity between birth and age 17 years. We estimated adjusted risk ratios (RR) and hazard ratios (HR) with 95% confidence intervals (CI) for the association of maternal biliary disease with child outcomes.

Results: A total of 95,047 children (7.5%) had mothers with biliary disease. Compared with no exposure, maternal biliary disease was associated with an increased risk of bile duct defects (RR 1.67, 95% CI 1.10-2.52), liver defects (RR 1.47, 95% CI 1.05-2.06), and inborn errors of metabolism (RR 1.41, 95% CI 1.24-1.62) in offspring. Exposed children were more likely to be hospitalized for cholelithiasis, cholecystitis, or cholangitis (HR 2.58, 95% CI 2.14-3.12), acute pancreatitis (HR 1.83, 95% CI 1.38-2.43), and metabolic dysfunction-associated steatotic liver disease (HR 2.71, 95% CI 2.07-3.54).

Conclusions: Maternal biliary disease is associated with hepatopancreatobiliary complications in offspring.

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母体胆道疾病与后代肝胆管发病率的关系

目的：母体胆道疾病是常见的，但与后代肝胆道疾病的关系尚未研究。我们评估了母亲胆道疾病与儿童肝胆管发病率之间的关系。方法：我们对加拿大魁北克省2006年至2022年间出生的1,271,864名儿童进行了回顾性队列研究。暴露是母体胆道疾病。后代结局包括先天性肝胆管异常、先天性代谢错误和出生至17岁之间的肝胆管发病率。我们估计了校正风险比（RR）和危险比（HR），其95%置信区间（CI）为母亲胆道疾病与儿童结局的关联。结果：共有95047名儿童（7.5%）的母亲患有胆道疾病。与未暴露相比，母体胆道疾病与后代胆管缺陷（RR 1.67, 95% CI 1.10-2.52）、肝脏缺陷（RR 1.47, 95% CI 1.05-2.06）和先天性代谢错误（RR 1.41, 95% CI 1.24-1.62）的风险增加相关。暴露的儿童更容易因胆石症、胆囊炎或胆管炎住院（HR 2.58, 95% CI 2.14-3.12），急性胰腺炎（HR 1.83, 95% CI 1.38-2.43）和代谢功能障碍相关的脂肪变性肝病（HR 2.71, 95% CI 2.07-3.54）。结论：母体胆道疾病与后代的肝胆胰并发症有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Gastroenterology and Nutrition 医学-胃肠肝病学

CiteScore

5.30

自引率

13.80%

发文量

467

审稿时长

3-6 weeks

期刊介绍： The Journal of Pediatric Gastroenterology and Nutrition (JPGN) provides a forum for original papers and reviews dealing with pediatric gastroenterology and nutrition, including normal and abnormal functions of the alimentary tract and its associated organs, including the salivary glands, pancreas, gallbladder, and liver. Particular emphasis is on development and its relation to infant and childhood nutrition.