Corneal Sealants in Pre-Clinical Development.

IF 2 4区医学 Q3 OPHTHALMOLOGY

Current Eye Research Pub Date : 2025-10-07 DOI:10.1080/02713683.2025.2566853

Jackie Tan, Leslie John Ray Foster, Frank James Lovicu, Yogambha Ramaswamy, Gurvinder Singh, Stephanie Louise Watson

{"title":"Corneal Sealants in Pre-Clinical Development.","authors":"Jackie Tan, Leslie John Ray Foster, Frank James Lovicu, Yogambha Ramaswamy, Gurvinder Singh, Stephanie Louise Watson","doi":"10.1080/02713683.2025.2566853","DOIUrl":null,"url":null,"abstract":"Purpose: To examine corneal sealants and adhesives in the pre-clinical phase of development to guide future development.Method: A systematic review of major databases from inception to 4th March 2025.Results: Corneal sealants and adhesives can be broadly divided into biological and synthetic groups. These are further categorized by their methods of adhesion activation. This review identified the following groups: human fibrin glue, cyanoacrylates, biodendrimers, polyethylene glycol, fibrinogen, albumin, collagen, gelatin, chondroitin, hyaluronic acid, dextran, and chitosan. Burst pressures are often reported as a measure of sealing efficacy. Ideal characteristics for future development include biocompatibility, tolerate high burst pressure, on-demand activation, accelerates healing, and does no transmit infection.Conclusion: A variety of corneal sealants and adhesives are in development. To seal corneal wounds sealants and adhesive should have a range of properties to prevent leak.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-16"},"PeriodicalIF":2.0000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Eye Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02713683.2025.2566853","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To examine corneal sealants and adhesives in the pre-clinical phase of development to guide future development.

Method: A systematic review of major databases from inception to 4^th March 2025.

Results: Corneal sealants and adhesives can be broadly divided into biological and synthetic groups. These are further categorized by their methods of adhesion activation. This review identified the following groups: human fibrin glue, cyanoacrylates, biodendrimers, polyethylene glycol, fibrinogen, albumin, collagen, gelatin, chondroitin, hyaluronic acid, dextran, and chitosan. Burst pressures are often reported as a measure of sealing efficacy. Ideal characteristics for future development include biocompatibility, tolerate high burst pressure, on-demand activation, accelerates healing, and does no transmit infection.

Conclusion: A variety of corneal sealants and adhesives are in development. To seal corneal wounds sealants and adhesive should have a range of properties to prevent leak.

查看原文本刊更多论文

临床前开发的角膜密封剂。

目的：探讨角膜密封剂和粘接剂在临床前阶段的发展情况，指导未来的发展。方法：对各大数据库从成立到2025年3月4日进行系统回顾。结果：角膜密封剂和粘接剂大致可分为生物类和合成类。根据它们的粘附激活方法进一步分类。本综述确定了以下几种：人纤维蛋白胶、氰丙烯酸酯、生物树突、聚乙二醇、纤维蛋白原、白蛋白、胶原蛋白、明胶、软骨素、透明质酸、葡聚糖和壳聚糖。破裂压力常被报道为密封效果的一种衡量标准。未来发展的理想特性包括生物相容性，耐受高破裂压力，按需激活，加速愈合，不传播感染。结论：各种角膜密封剂和胶粘剂正在开发中。为了密封角膜伤口，密封剂和粘合剂应具有一系列防止泄漏的性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.