Management of vestibular schwannoma in the elderly.

Q2 Medicine
Ahmed Helal, Mathew L Carlson, Michael J Link
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引用次数: 0

Abstract

The elderly population has been expanding and is expected to continue to do so in the future. This, together with advances in work-up for SNHL, led to an increase in the incidence of VS, with smaller tumor sizes and older ages at the time of diagnosis. One-third of VS exhibit growth, with an average growth rate of 2mm/year. Larger extracanalicular tumors are more likely to grow independent of patient age. Patients with higher baseline SDS fare better, and those managed conservatively have a higher preservation of facial function. Despite extensive research, standardized treatment for VS has yet to be implemented, especially in the elderly population, given the many individual variations. Watchful waiting is a reasonable option for smaller tumors, especially on initial follow-up, providing the highest rates of hearing and facial nerve preservation. An alternative option, which is especially advantageous in high-risk elderly populations, is radiosurgery, providing more than 94% tumor control rate with roughly 57% hearing preservation rate on long-term follow-up. Radiosurgery may be used alone or as an adjunct to microsurgery. Finally, microsurgery remains a feasible option for properly selected elderly patients with reasonable surgical risk, and large Koos grade 4 tumors generally not amenable to radiosurgery.

老年人前庭神经鞘瘤的治疗。
老年人口一直在增加,预计今后还会继续增加。这一点,再加上SNHL检查的进展,导致VS的发病率增加,肿瘤大小更小,诊断时年龄更大。三分之一的VS呈现增长,平均增长率为2mm/年。较大的管外肿瘤更可能与患者年龄无关。基线SDS较高的患者预后较好,保守治疗的患者面部功能保存较好。尽管进行了广泛的研究,但鉴于许多个体差异,对VS的标准化治疗尚未实施,特别是在老年人群中。观察等待对于较小的肿瘤是一个合理的选择,特别是在最初的随访中,提供最高的听力和面神经保留率。另一种选择是放射手术,在高风险的老年人群中尤其有利,在长期随访中提供超过94%的肿瘤控制率和大约57%的听力保留率。放射外科可以单独使用,也可以作为显微外科的辅助手段。最后,对于有合理手术风险的老年患者,显微手术仍然是一个可行的选择,而大的Koos 4级肿瘤通常不适合放射手术。
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来源期刊
Handbook of clinical neurology
Handbook of clinical neurology Medicine-Neurology (clinical)
CiteScore
4.10
自引率
0.00%
发文量
302
期刊介绍: The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.
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