Investigating Aberrant Salience in Autism Spectrum Disorder and Psychosis Risk: A Cross-Group Analysis

IF 2.2 4区医学 Q3 PSYCHIATRY

Early Intervention in Psychiatry Pub Date : 2025-10-06 DOI:10.1111/eip.70099

Federico Fiori Nastro, Martina Pelle, Alice Clemente, Fernando Corinto, Davide Prosperi Porta, Yael Sonnino, Carmine Gelormini, Giorgio Di Lorenzo, Michele Ribolsi

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Abstract

Aim

This study investigates the expression of aberrant salience (AS) in individuals with autism spectrum disorder (ASD), those at clinical high risk for psychosis (CHR-P) and help-seeking individuals without formal diagnoses.

Methods

Ninety-nine participants, 44 males and 55 females (age range 17–39 years), met the inclusion criteria of absence of major neurological disorders, intellectual disabilities or substance-related conditions. None were receiving antipsychotic treatment. Based on clinical evaluations, participants were categorised into three groups: ASD (n = 23), Attenuated Psychosis Syndrome (APS) (n = 27) and help-seekers (n = 49). The Aberrant Salience Inventory (ASI) was administered.

Results

Significant differences were observed in ASI total and subscale scores among groups. Post hoc analyses showed significantly higher ASI scores in the ASD and APS groups compared to help-seekers, but no significant differences between ASD and APS.

Conclusions

These findings suggest an overlap in AS processing between ASD and psychosis-spectrum conditions, supporting AS as a transdiagnostic construct.

Abstract Image

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研究自闭症谱系障碍和精神病风险的异常显著性：一项跨组分析。

目的：探讨异常显著性（aberrant salience， AS）在自闭症谱系障碍（autism spectrum disorder， ASD）、临床精神病高危人群（clinical high risk for psychosis, chrp）和无正式诊断的求助者中的表达。方法：99例受试者，男44例，女55例，年龄17-39岁，符合无重大神经系统疾病、智力残疾或物质相关疾病的纳入标准。没有人接受抗精神病药物治疗。根据临床评估，参与者被分为三组：ASD (n = 23)，减轻精神病综合征（APS）（n = 27）和寻求帮助者（n = 49）。进行异常显著性量表（ASI）。结果：两组间ASI总分和亚量表得分均有显著差异。事后分析显示，与寻求帮助者相比，ASD组和APS组的ASI得分明显更高，但ASD组和APS组之间没有显著差异。结论：这些发现表明，在ASD和精神病谱系条件之间，AS的加工有重叠，支持AS作为一种跨诊断结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.