Associations of Graded Chronic Non-Cancer Pain Severity With Well-Being and Modifiable Lifestyle Behaviour: Findings From a Danish Population-Based Cross-Sectional Survey

IF 3.4 2区医学 Q1 ANESTHESIOLOGY

European Journal of Pain Pub Date : 2025-10-07 DOI:10.1002/ejp.70138

Sophie Sell Hellmann, Henrik Bjarke Vaegter, Gitte Handberg, Pernille Lykke Petersen, Geana Paula Kurita, Per Sjøgren, Lau Caspar Thygesen, Ola Ekholm

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引用次数: 0

Abstract

Background

The Graded Chronic Pain Scale-Revised (GCPS-R) framework enables a standardised measure of disease severity and was incorporated into the national disease surveillance in Denmark in 2023. Novel dose–response associations between GCPS-R-systemised disease severity, general health, well-being, and modifiable lifestyle behaviour were analysed to enhance awareness of risk associations related to chronic non-cancer pain disease severity.

Methods

A cross-sectional study including 8329 non-cancer participants aged 16 years and older from the Danish National Health Survey 2023. The participants completed a comprehensive self-reported questionnaire on general health, well-being, and modifiable lifestyle behaviour, including the GCPS-R framework. Multivariate-adjusted odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using logistic regression models for dichotomous outcomes related to general health, well-being, and modifiable lifestyle behaviour adjusted for sex, age, area of residence, BMI, country of origin, education and marital status.

Results

The GCPS-R score had strong positive dose–response associations with odds of poor/fair general health, showing ORs 1.66 (95% CI: 1.32–2.10) in mild-impact, 6.08 (5.02–7.37) in bothersome-impact, and 13.53 (11.53–15.88) in high-impact compared with no chronic non-cancer pain. The GCPS-R score had overall strong positive associations with odds of poor well-being outcomes and moderate positive associations with odds of unhealthy modifiable lifestyle behaviour outcomes concerning illicit drugs, obesity, sedentary lifestyle, unhealthy diet and tobacco.

Conclusions

The GCPS-R framework is applicable in national surveys enabling graded measures for associations related to chronic non-cancer pain disease severity. Unified cross-country strategies for national surveillance could strengthen the evidence base for equitable public health policies.

Significance Statement

Chronic non-cancer pain is a highly prevalent disease associated with elevated risks of several bio- psychosocial health conditions. However, whether risks related to chronic non-cancer pain vary by disease severity is currently unknown. Hellmann et al. found the validated GCPS-R framework useful in national survey-based disease surveillance. The GCPS-R-systemised disease severity measures classified in no, low-impact, bothersome-impact, and high-impact chronic non-cancer pain enabled nuanced knowledge about such risk associations, being a fundamental base in planning targeted healthcare strategies for improved chronic non-cancer pain management.

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分级慢性非癌症疼痛严重程度与幸福感和可改变的生活方式行为的关联：来自丹麦人群的横断面调查结果。

背景：分级慢性疼痛量表-修订（GCPS-R）框架实现了疾病严重程度的标准化测量，并于2023年被纳入丹麦的国家疾病监测。分析了gcps -r系统化疾病严重程度、一般健康、幸福感和可改变的生活方式行为之间的新型剂量-反应关联，以提高对慢性非癌性疼痛疾病严重程度相关风险关联的认识。方法：一项横断面研究，包括来自2023年丹麦国家健康调查的8329名年龄在16岁及以上的非癌症参与者。参与者完成了一份关于一般健康、幸福和可改变的生活方式行为的综合自我报告问卷，包括GCPS-R框架。使用逻辑回归模型计算与一般健康、幸福和可改变的生活方式行为相关的二分类结果，并根据性别、年龄、居住地区、BMI、原籍国、教育程度和婚姻状况进行调整，并计算具有95%置信区间（95% CI）的多变量调整优势比（OR）。结果：与无慢性非癌性疼痛的患者相比，GCPS-R评分与一般健康状况差/一般健康状况的几率呈强正相关，轻度影响的or值为1.66 (95% CI: 1.32-2.10)，重度影响的or值为6.08(5.02-7.37)，重度影响的or值为13.53（11.53-15.88）。总体而言，GCPS-R评分与不良幸福感结果的几率呈正相关，与不健康的可改变生活方式行为结果的几率呈正相关，包括非法药物、肥胖、久坐不动的生活方式、不健康的饮食和烟草。结论：GCPS-R框架适用于国家调查，可对与慢性非癌症疼痛疾病严重程度相关的关联进行分级测量。统一的国家监测跨国战略可以加强公平的公共卫生政策的证据基础。意义声明：慢性非癌性疼痛是一种高度流行的疾病，与几种生物-社会心理健康状况的风险升高相关。然而，慢性非癌性疼痛的相关风险是否因疾病严重程度而异，目前尚不清楚。Hellmann等人发现，经过验证的GCPS-R框架在国家基于调查的疾病监测中很有用。gcps - r系统的疾病严重程度测量分为无、低影响、麻烦影响和高影响慢性非癌性疼痛，使人们能够细致入微地了解这些风险关联，成为规划有针对性的医疗保健策略以改善慢性非癌性疼痛管理的基础。

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.