The PI3K/AKT/mTOR Pathway and Oral Diseases: A Bibliometric Analysis From 2008 to 2025.

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research Pub Date : 2025-10-01 DOI:10.1002/cre2.70238

Yena Gan, Duoduo Li, He Xu, Sheng Han, He Zhu, Zening Wei, Zhigang Cai, Jinwei Huang

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引用次数: 0

Abstract

Objectives: The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is a key therapeutic target for oral diseases. This study uses bibliometric analysis to identify research trends, knowledge gaps, and the development of PI3K/AKT/mTOR-targeted therapies.

Methods: A systematic literature search was conducted in March 2025 using the keywords "PI3K/AKT/mTOR" and "dental OR oral." Publication trends, highly cited studies, research hotspots, and emerging trends were analyzed. Comparative analyses of publication year, study design, and disease categories were performed between Asian and non-Asian cohorts.

Results: From 2008 to 2025, 119 studies were identified, with China, India, and Japan leading in publications and citations. Germany had the highest average citations. Keyword analysis showed a shift from basic to clinical research. Of these studies, 91 were from Asia, covering a broader range of oral conditions, while 28 were from non-Asian regions, with no significant differences in study design or disease categories.

Conclusion: This bibliometric analysis shows rising global interest in PI3K/AKT/mTOR research in oral science, led by Asia. Research has shifted from basic signaling to disease-focused studies, with future efforts focusing on underexplored oral pathologies and translational applications, particularly in targeted therapy and regenerative medicine.

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PI3K/AKT/mTOR通路与口腔疾病：2008 - 2025年文献计量学分析

目的：磷酸肌肽3激酶(PI3K)/蛋白激酶B (AKT)/哺乳动物雷帕霉素靶点（mTOR）信号通路是口腔疾病的关键治疗靶点。本研究使用文献计量学分析来确定研究趋势、知识差距以及PI3K/AKT/ mtor靶向治疗的发展。方法：于2025年3月以“PI3K/AKT/mTOR”和“dental OR oral”为关键词进行系统文献检索。分析了出版物趋势、高被引研究、研究热点和新兴趋势。在亚洲和非亚洲队列之间进行了发表年份、研究设计和疾病类别的比较分析。结果：从2008年到2025年，共确定了119项研究，其中中国、印度和日本在发表和引用方面处于领先地位。德国的平均引用次数最高。关键词分析显示从基础研究到临床研究的转变。在这些研究中，91项来自亚洲，涵盖了更广泛的口腔状况，而28项来自非亚洲地区，在研究设计或疾病类别方面没有显著差异。结论：这项文献计量分析显示，全球对口腔科学中PI3K/AKT/mTOR研究的兴趣正在上升，以亚洲为首。研究已经从基础信号转向以疾病为重点的研究，未来的努力将集中在尚未开发的口腔病理学和转化应用，特别是在靶向治疗和再生医学方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.