{"title":"Applications of recombinant type III collagen in tissue engineering.","authors":"Yuchen Shan, Ting Wang, Haiyan Lin","doi":"10.1186/s12938-025-01447-9","DOIUrl":null,"url":null,"abstract":"<p><p>Recombinant human type III collagen (rhCol III) is a promising biomaterial for tissue engineering due to its excellent biocompatibility and bioactivity. This review summarizes the structure, development, and applications of rhCol III in bone and soft tissue engineering. Advances in genetic engineering have enabled the production of rhCol III with customizable properties. It plays a key role in promoting tissue repair and regeneration, with significant potential in wound healing, skin repair, and anti-inflammatory responses. However, challenges remain in optimizing its mechanical properties for specific applications. Future research should focus on improving production efficiency and clinical translation while addressing potential host responses.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"114"},"PeriodicalIF":2.9000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioMedical Engineering OnLine","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1186/s12938-025-01447-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Recombinant human type III collagen (rhCol III) is a promising biomaterial for tissue engineering due to its excellent biocompatibility and bioactivity. This review summarizes the structure, development, and applications of rhCol III in bone and soft tissue engineering. Advances in genetic engineering have enabled the production of rhCol III with customizable properties. It plays a key role in promoting tissue repair and regeneration, with significant potential in wound healing, skin repair, and anti-inflammatory responses. However, challenges remain in optimizing its mechanical properties for specific applications. Future research should focus on improving production efficiency and clinical translation while addressing potential host responses.
期刊介绍：
BioMedical Engineering OnLine is an open access, peer-reviewed journal that is dedicated to publishing research in all areas of biomedical engineering.
BioMedical Engineering OnLine is aimed at readers and authors throughout the world, with an interest in using tools of the physical and data sciences and techniques in engineering to understand and solve problems in the biological and medical sciences. Topical areas include, but are not limited to:
Bioinformatics-
Bioinstrumentation-
Biomechanics-
Biomedical Devices & Instrumentation-
Biomedical Signal Processing-
Healthcare Information Systems-
Human Dynamics-
Neural Engineering-
Rehabilitation Engineering-
Biomaterials-
Biomedical Imaging & Image Processing-
BioMEMS and On-Chip Devices-
Bio-Micro/Nano Technologies-
Biomolecular Engineering-
Biosensors-
Cardiovascular Systems Engineering-
Cellular Engineering-
Clinical Engineering-
Computational Biology-
Drug Delivery Technologies-
Modeling Methodologies-
Nanomaterials and Nanotechnology in Biomedicine-
Respiratory Systems Engineering-
Robotics in Medicine-
Systems and Synthetic Biology-
Systems Biology-
Telemedicine/Smartphone Applications in Medicine-
Therapeutic Systems, Devices and Technologies-
Tissue Engineering
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