Thiol-Ene Click Hydrogels From Pentaerythritol Tetrakis(3-Mercaptopropionate) and Polyethylene Glycol Diacrylate: Mucoadhesive and Antimicrobial Platforms for Drug Delivery

IF 2.8 3区化学 Q2 POLYMER SCIENCE

Journal of Applied Polymer Science Pub Date : 2025-07-18 DOI:10.1002/app.57644

Diara S. Kazybayeva, Danelya N. Makhayeva, Vitaliy V. Khutoryanskiy, Grigoriy A. Mun, Galiya S. Irmukhametova

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Abstract

Hydrogels with mucoadhesive properties offer significant potential for drug delivery due to their tunable physicochemical characteristics and sustained drug release capabilities. This research investigates polymer hydrogels synthesized via thiol-ene click reactions between pentaerythritol tetrakis(3-mercaptopropionate) (PEMP) and polyethylene glycol diacrylate (PEGDA), exploring their potential as effective mucoadhesive and antimicrobial drug delivery systems. Sol–gel analysis revealed that gel formation efficiency depends on the acrylate-to-thiol ratio, with stoichiometric formulations yielding higher gel fractions. FTIR spectroscopy and elemental analysis confirmed the chemical composition of these hydrogels, showing the presence of residual CC bonds and a decrease in thiol group content with increasing PEGDA concentration. The mechanical properties were superior in hydrogels prepared using stoichiometric (1:1) ratios of the reagents, while mucoadhesiveness—tested on ovine vaginal tissue—was enhanced in samples with higher thiols-bearing PEMP content. Drug loading efficiency and release kinetics were evaluated for clindamycin phosphate and clotrimazole. Hydrophilic gels showed greater clindamycin loading and more sustained release compared to clotrimazole. Antimicrobial testing demonstrated that clindamycin-loaded hydrogels exhibited strong antibacterial activity against Staphylococcus aureus . Clotrimazole-loaded hydrogels showed less pronounced antifungal effects against Candida albicans . These findings highlight the applicability of PEGDA-PEMP hydrogels for mucoadhesive drug delivery and antimicrobial applications.

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由季戊四醇四醇（3-巯基丙酸）和聚乙二醇二丙烯酸酯制成的巯基点击水凝胶：用于药物输送的黏合剂和抗菌平台

具有黏附特性的水凝胶由于其可调节的物理化学特性和持续的药物释放能力，为药物输送提供了巨大的潜力。本研究研究了季戊四醇四（3-巯基丙酸）（PEMP）和聚乙二醇二丙烯酸酯（PEGDA）之间通过巯基键合反应合成的聚合物水凝胶，探索其作为有效黏附和抗菌药物递送系统的潜力。溶胶-凝胶分析表明，凝胶形成效率取决于丙烯酸酯与硫醇的比例，化学计量配方产生更高的凝胶分数。FTIR光谱和元素分析证实了这些水凝胶的化学组成，表明随着PEGDA浓度的增加，存在残余的C - - C键，巯基含量降低。以化学计量（1:1）比例制备的水凝胶的力学性能更优，而在羊阴道组织上测试的黏附性在含有较高硫醇含量的样品中得到增强。对克林霉素磷酸和克霉唑的载药效率和释放动力学进行了评价。与克霉唑相比，亲水性凝胶表现出更大的克林霉素负载和更持久的释放。抗菌试验表明，载克林霉素水凝胶对金黄色葡萄球菌具有较强的抗菌活性。氯霉唑水凝胶对白色念珠菌的抗真菌作用不明显。这些发现突出了PEGDA-PEMP水凝胶在黏附给药和抗菌应用方面的适用性。

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来源期刊

Journal of Applied Polymer Science 化学-高分子科学

CiteScore

5.70

自引率

10.00%

发文量

1280

审稿时长

2.7 months

期刊介绍： The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.