Unveiling the transformative horizon of biopolymers in drug delivery

IF 4 3区化学 Q2 POLYMER SCIENCE

Polymer Bulletin Pub Date : 2025-07-07 DOI:10.1007/s00289-025-05919-9

Pranjal Mishra, Braj Rawat, Kantrol Kumar Sahu, Wasim Akram

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引用次数: 0

Abstract

The landscape of drug delivery is experiencing a paradigm shift catalyzed by the transformative potential of biopolymers. Derived from natural sources such as chitosan, alginate, and gelatin, these polymers offer inherent advantages including biocompatibility, biodegradability, and versatility, making them highly desirable for precision drug delivery systems. Across various routes of administration including oral, transdermal, injectable, ocular, and targeted delivery, biopolymers showcase unparalleled levels of precision and patient-centricity. From advanced nanoformulations and microbiome-targeted systems in oral delivery to microneedle arrays and hydrogel dressings in transdermal delivery, biopolymers drive innovation. Injectable systems featuring smart hydrogels and cellular targeting exemplify the shift toward minimally invasive yet highly effective treatments. Ocular and targeted delivery, particularly in cancer therapeutics, witness groundbreaking advancements facilitated by biopolymers, promising enhanced bioavailability and specificity. Current research trends highlight the potential for personalized medicine with multifunctional nanoparticles and stimuli-responsive polymers, offering tailored treatments for improved efficacy and therapeutic outcomes. As the transformative horizon of biopolymers in drug delivery continues to unfold, we stand on the brink of a new era characterized by innovation, sustainability, and enhanced patient care, promising to revolutionize pharmaceutical sciences for the foreseeable future.

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揭示生物聚合物在药物输送中的变革前景

在生物聚合物的变革潜力的催化下，给药领域正在经历一场范式转变。这些聚合物来源于天然来源，如壳聚糖、海藻酸盐和明胶，具有生物相容性、可生物降解性和多功能性等固有优势，使其成为精确给药系统的理想选择。在各种给药途径中，包括口服、透皮、注射、眼和靶向给药，生物聚合物显示出无与伦比的精确度和以患者为中心的水平。从口服给药的先进纳米配方和微生物组靶向系统，到透皮给药的微针阵列和水凝胶敷料，生物聚合物推动了创新。具有智能水凝胶和细胞靶向的注射系统是向微创但高效治疗转变的例证。眼部和靶向递送，特别是在癌症治疗中，见证了生物聚合物促进的突破性进展，有望提高生物利用度和特异性。目前的研究趋势强调了多功能纳米颗粒和刺激反应聚合物的个性化医疗潜力，为提高疗效和治疗结果提供量身定制的治疗方法。随着生物聚合物在给药领域的变革不断展开，我们正站在一个以创新、可持续性和增强患者护理为特征的新时代的边缘，有望在可预见的未来彻底改变制药科学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymer Bulletin 化学-高分子科学

CiteScore

6.00

自引率

6.20%

发文量

审稿时长

5.5 months

期刊介绍： "Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad. "Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."