Enrichment of Biological Activity of Strontium-Doped Borate Glass for Bone Replacement through Nanosecond Laser Irradiation

Abstract

In recent years, bioactive glasses have gained significant attention as potential systems for bone regeneration due to their excellent bioactivity and therapeutic properties. The addition of Sr²⁺ ions, known for their osteogenic potential, is a promising strategy for enhancing the bone regeneration characteristics of bioactive glasses. Laser irradiation, which can alter the properties of bioactive glasses, presents unique opportunities for boosting bone regeneration. This study involved preparing glass samples based on the B₂O₃, 24.5 CaO, 24.5 Na₂O, and 6 P₂O₅ system, incorporating different percentages (5 and 10 wt.%) of SrO using melt quenching techniques. The samples were subjected to irradiation using the Nd: YAG nanosecond laser method. The in vitro bioactivity in simulated bodily fluid (SBF) was examined, and the findings were found to be excellent after laser irradiation. SEM pictures revealed a cotton-like shape, FTIR spectra revealed split peak formations, and ultraviolet and visible spectroscopy revealed enhanced optical properties, all confirming the presence of the hydroxyapatite layer following laser irradiation. The application of nanosecond laser irradiation in conjunction with borate glass containing strontium holds tremendous promise for the development of new bone regeneration procedures.