Synthesis, Structure, and Biological Activity of New Coordination Compounds of Selected 3d-Metals with 4,S-Diallylisothiosemicarbazones of 2-Formyl- and 2-Acetylpyridine

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-10-07 DOI:10.1134/S1070363225604521

I. S. Usataia, V. O. Graur, P. N. Bourosh, E. I. Melnic, G. G. Balan, C. S. Lozan-Tirsu, O. S. Garbuz, A. P. Gulea

{"title":"Synthesis, Structure, and Biological Activity of New Coordination Compounds of Selected 3d-Metals with 4,S-Diallylisothiosemicarbazones of 2-Formyl- and 2-Acetylpyridine","authors":"I. S. Usataia, V. O. Graur, P. N. Bourosh, E. I. Melnic, G. G. Balan, C. S. Lozan-Tirsu, O. S. Garbuz, A. P. Gulea","doi":"10.1134/S1070363225604521","DOIUrl":null,"url":null,"abstract":"Eight novel coordination compounds of nickel(II), cobalt(III), and iron(III) with 4,S-diallylisothiosemicarbazones of 2-formylpyridine (HL1) and 2-acetylpyridine (HL2) were synthesized: [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Ni(HL1)2](I)2, [Co(L1)2]I, [Co(L2)2]I, [Fe(L1)2]NO3, [Fe(L1)2]Br, [Fe(L2)2]NO3. The isothiosemicarbazone ligands were characterized by NMR and IR spectroscopy. All coordination compounds were characterized by elemental analysis, IR spectroscopy, and molar conductivity measurements of their 1 mM solutions in methanol. Furthermore, the crystal structures of the complexes [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Ni(HL1)2](I)2 were determined by single-crystal X-ray diffraction (SC-XRD). The investigated complexes exhibited antibacterial, antifungal, and antiradical activity against ABTS•+ cation radicals. The complexes [Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Co(L1)2]I, [Fe(L1)2]NO3 demonstrated superior antiradical activity compared to Trolox, a standard antioxidant used in medical practice.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 9","pages":"2390 - 2401"},"PeriodicalIF":0.8000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363225604521","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Eight novel coordination compounds of nickel(II), cobalt(III), and iron(III) with 4,S-diallylisothiosemicarbazones of 2-formylpyridine (HL¹) and 2-acetylpyridine (HL²) were synthesized: [Ni(HL¹)₂](NO₃)₂, [Ni(HL²)₂](NO₃)₂∙2H₂O, [Ni(HL¹)₂](I)₂, [Co(L¹)₂]I, [Co(L²)₂]I, [Fe(L¹)₂]NO₃, [Fe(L¹)₂]Br, [Fe(L²)₂]NO₃. The isothiosemicarbazone ligands were characterized by NMR and IR spectroscopy. All coordination compounds were characterized by elemental analysis, IR spectroscopy, and molar conductivity measurements of their 1 mM solutions in methanol. Furthermore, the crystal structures of the complexes [Ni(HL¹)₂](NO₃)₂, [Ni(HL²)₂](NO₃)₂∙2H₂O, [Ni(HL¹)₂](I)₂ were determined by single-crystal X-ray diffraction (SC-XRD). The investigated complexes exhibited antibacterial, antifungal, and antiradical activity against ABTS^•+ cation radicals. The complexes [Ni(HL¹)₂](NO₃)₂, [Ni(HL²)₂](NO₃)₂∙2H₂O, [Co(L¹)₂]I, [Fe(L¹)₂]NO₃ demonstrated superior antiradical activity compared to Trolox, a standard antioxidant used in medical practice.

Abstract Image

查看原文本刊更多论文

与2-甲酰基和2-乙酰吡啶的4，s -二烯基异硫代氨基脲基金属配位化合物的合成、结构和生物活性

合成了镍（II）、钴（III）、铁（III）与2-甲酰基吡啶（HL1）和2-乙酰吡啶（HL2）的4，s -二烯丙基异硫代氨基脲类化合物[Ni(HL1)2](NO3)2、[Ni(HL2)2](NO3)2∙2H2O、[Ni(HL1)2](I)2、[Co(L1)2]I、[Fe(L1)2]NO3、[Fe(L2)2] Br、[Fe(L2)2]NO3。用核磁共振和红外光谱对异硫代氨基脲配体进行了表征。通过元素分析、红外光谱和1 mM甲醇溶液的摩尔电导率测量对所有配位化合物进行了表征。利用单晶x射线衍射（SC-XRD）测定了配合物[Ni(HL1)2](NO3)2、[Ni(HL2)2](NO3)2∙2H2O、[Ni(HL1)2](I)2的晶体结构。所研究的配合物对ABTS•+阳离子自由基具有抗菌、抗真菌和抗自由基活性。与医疗实践中使用的标准抗氧化剂Trolox相比，配合物[Ni(HL1)2](NO3)2, [Ni(HL2)2](NO3)2∙2H2O, [Co(L1)2]I, [Fe(L1)2]NO3表现出更强的抗自由基活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.