Calorimetric Study for the Hydrolysis of Acetonitrile Catalyzed by Acids or Bases

IF 3.5 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2025-10-07 DOI:10.1021/acs.oprd.5c00171

Jianwen Chen, Youwei Chen, Min Sheng

引用次数: 0

Abstract

The acid/base-acetonitrile (ACN) mixed system finds extensive application in numerous modern reaction processes. This study investigates the reactions of ACN with mixed aqueous solutions of different concentrations of sulfuric acid, hydrochloric acid, sodium hydroxide, and potassium hydroxide. The results show that heat is generated to varying degrees, and it was found that as the concentration of the strong acid or strong base solutions increases, the amount of heat produced also increases. Particularly under high-concentration conditions, strong acids and bases can induce exothermic hydrolysis of ACN at ambient temperature. Proper use of ACN with mixed solutions of strong acids and strong bases can help prevent safety incidents and also provide insights for future research on the hydrolysis reactions of ACN as a solvent.

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酸或碱催化乙腈水解的量热研究

酸/碱-乙腈（ACN）混合体系在许多现代反应过程中有着广泛的应用。本研究考察了ACN与不同浓度硫酸、盐酸、氢氧化钠和氢氧化钾的混合水溶液的反应。结果表明，不同程度地产生热量，并发现随着强酸或强碱溶液浓度的增加，产生的热量也随之增加。特别是在高浓度条件下，强酸和强碱可以在室温下诱导ACN的放热水解。正确使用ACN与强酸强碱混合溶液可以防止安全事故的发生，也为今后ACN作为溶剂的水解反应研究提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.