Direct Access to 1,3-Enynes from Skipped Enynes via HFIP-Promoted Allylic Substitution Reaction

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-10-06 DOI:10.1021/acs.joc.5c01618

Srinivasarao Yaragorla*, , , Aayesha Shaik, , and , Vinod Megavath,

引用次数: 0

Abstract

A simple, efficient, and metal-free protocol for the synthesis of highly functionalized 1,3-enynes has been developed from skipped enynes by a direct nucleophilic substitution reaction in HFIP at room temperature in open air. This metal-free approach offers a broad substrate scope with excellent yields, Z-selective enynes, and atom economy.

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通过hfip促进的烯丙基取代反应直接从跳过的烯丙基中获得1,3-炔。

通过室温下的HFIP直接亲核取代反应，建立了一种简单、高效、无金属的高功能化1,3-炔合成方法。这种无金属的方法提供了广泛的衬底范围，具有优异的产率，z选择性烯和原子经济性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.