Natural variation of GNP2 enhances grain number to benefit rice yield.

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2025-10-06 DOI:10.1038/s41467-025-64564-y

Qianfeng Hu,Zhikun Zhao,Lingling Ma,Haijian Xia,Zhiqi Ma,Penghui Xu,Xianpeng Wang,Rui Zhu,Yong Zhao,Haifeng Guo,Xiaoyang Zhu,Yawen Zeng,Yinghua Pan,Danting Li,Xingming Sun,Jinjie Li,Hongliang Zhang,Zichao Li,Zhanying Zhang

引用次数: 0

Abstract

Natural variations provide valuable genetic resources for improving rice grain number per panicle (GNP). Here, our genome-wide association study (GWAS) identifies GNP2 and GNP5 as key regulators of GNP that enhance rice yield. GNP5 encodes a bZIP transcription factor binding to the S5779181 locus in the GNP2 promoter, where natural variation significantly influences GNP. GNP2 encodes a conserved GSK3-like kinase that phosphorylates and stabilizes Gnp4/LAX2. The phosphorylated Gnp4/LAX2T175,262D promotes yield by modulating transcription factors involved in panicle development. Haplotype analysis reveals an elite allele combination (Type I) of GNP5 and GNP2 that significantly increases GNP. Field trials demonstrate that enhanced GNP2 expression raises yield by approximately 10%. Our findings thus uncover a genetic resource with application potential for enhancing rice yield.

查看原文本刊更多论文

GNP2的自然变异增加籽粒数，有利于水稻产量。

自然变异为提高水稻每穗粒数提供了宝贵的遗传资源。在此，我们的全基因组关联研究（GWAS）发现GNP2和GNP5是GNP提高水稻产量的关键调控因子。GNP5编码一个bZIP转录因子，与GNP2启动子的S5779181位点结合，该位点的自然变异显著影响GNP。GNP2编码一个保守的gsk3样激酶，磷酸化和稳定Gnp4/LAX2。磷酸化的Gnp4/LAX2T175,262D通过调节参与穗发育的转录因子来促进产量。单倍型分析显示，GNP5和GNP2的精英等位基因组合（I型）显著提高GNP。田间试验表明，GNP2表达增强可使产量提高约10%。因此，我们的发现揭示了一种具有提高水稻产量应用潜力的遗传资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.