Enzyme‐Based Electrochemical Sensing Systems for On‐Site Detection: Recent Progress and Prospects

IF 12.1 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-10-07 DOI:10.1002/smll.202507926

Huiwen Wang, Cong Liu, Tingting Feng, Yanfei Zhang, Yanfang Wu, Zong Dai, Changqing Yi

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引用次数: 0

Abstract

The growing demand for rapid and reliable health monitoring drives significant advancements in enzyme‐based electrochemical sensors for point‐of‐care testing (POCT) applications. This review highlights recent developments in enzyme electrode technology, with a focus on surface modifications, immobilization techniques, and electrode materials that significantly enhance sensor stability, sensitivity, and accuracy in detecting critical health biomarkers. The integration of these electrochemical sensors with portable devices and smart technologies, enabled by innovative hardware and software designs, positions them as highly practical tools for clinical diagnostics and health monitoring. Despite these advances, several challenges persist in ensuring their broad applicability in diverse environments. This review explores these challenges and discusses future research directions. By providing these insights into current innovations and future possibilities, this review aims to serve as a valuable resource for researchers and foster the continued development of enzyme‐based electrochemical sensors in healthcare applications.

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基于酶的电化学传感系统用于现场检测：最新进展与展望

对快速可靠的健康监测的需求不断增长，推动了酶基电化学传感器在护理点检测（POCT）应用中的重大进步。这篇综述强调了酶电极技术的最新发展，重点是表面修饰、固定技术和电极材料，这些技术显著提高了传感器在检测关键健康生物标志物方面的稳定性、灵敏度和准确性。这些电化学传感器与便携式设备和智能技术的集成，通过创新的硬件和软件设计，使其成为临床诊断和健康监测的高度实用工具。尽管取得了这些进展，但在确保它们在不同环境中的广泛适用性方面仍然存在一些挑战。本文对这些挑战进行了探讨，并讨论了未来的研究方向。通过提供这些对当前创新和未来可能性的见解，本综述旨在为研究人员提供宝贵的资源，并促进酶基电化学传感器在医疗保健应用中的持续发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.