Oral Carbon Dots Derived from Cimicifugae rhizome Carbonization Products to Ameliorate Ulcerative Colitis

IF 8.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-10-07 DOI:10.1021/acsami.5c14857

Xiaozhuo Chen, , , Xi Luo, , , Meng Xiao, , , Xirui Chen, , , Lijiao Wu, , , Yu You*, , and , Jinming Zhang*,

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引用次数: 0

Abstract

Ulcerative colitis (UC) management remains challenging due to limitations of conventional therapies in disrupting the pathological cycle of ROS overproduction and gut microbiota dysbiosis. Inspired by traditional “carbonized herbs,” this study developed Cimicifugae rhizome-derived carbon dots (CR-CDs) by one-step pyrolysis. CR-CDs exhibited robust multienzyme mimetic (SOD/CAT-like) activity, effectively scavenging ROS and suppressing the LPS-stimulated inflammatory response in vitro. In dextran sulfate sodium (DSS)-induced murine colitis, orally administered CR-CDs accumulated preferentially in inflamed colon tissue and targeted macrophages. Treatment significantly alleviated UC symptoms and histological damage while restoring tight junction proteins and improving the Nrf2/HO-1 antioxidant signaling. Additionally, CR-CDs rebalanced gut microbiota composition, suppressing the pathogenic Aeromonas hydrophila and enriching beneficial Rikenellaceae/Muribaculaceae. By integrating traditional carbonization wisdom with nanotechnology, CR-CDs present a dual-functional therapeutic platform addressing both oxidative stress and microbial dysbiosis in UC, with significant potential for clinical translation.

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枸杞子炭化产品碳点口服治疗溃疡性结肠炎

溃疡性结肠炎（UC）的管理仍然具有挑战性，因为传统疗法在破坏ROS过量生产和肠道微生物群失调的病理循环方面存在局限性。受传统“炭化草本植物”的启发，本研究通过一步热解的方法开发了Cimicifugae根茎衍生的碳点（CR-CDs）。CR-CDs在体外表现出强大的多酶模拟（SOD/CAT-like）活性，有效清除ROS并抑制lps刺激的炎症反应。在葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎中，口服CR-CDs优先在炎症结肠组织和靶向巨噬细胞中积累。治疗可显著缓解UC症状和组织学损伤，同时恢复紧密连接蛋白，改善Nrf2/HO-1抗氧化信号。此外，CR-CDs重新平衡了肠道菌群组成，抑制了致病性的嗜水气单胞菌，并丰富了有益的Rikenellaceae/Muribaculaceae。通过将传统的碳化智慧与纳米技术相结合，CR-CDs提供了一种双重功能的治疗平台，可解决UC中的氧化应激和微生物生态失调问题，具有重要的临床应用潜力。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.