Preparation and properties of konjac glucomannan/P(N-isopropylacrylamide-crotonic acid) hydrogel

IF 4.5 2区化学 Q2 POLYMER SCIENCE

Polymer Pub Date : 2025-10-06 DOI:10.1016/j.polymer.2025.129181

Yajie Ding, Hua Ma, Chaoze Ji, Dingxiang Wei, Hongzhou Shang, Lihua Liu, Ning Qiao

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Abstract

A pH and temperature dual-responsive KGM/P(NIPAM-CA) hydrogel drug carrier was prepared by using natural polysaccharide konjac glucomannan (KGM), pH-sensitive monomer crotonic acid (CA), and temperature-sensitive monomer N-isopropylacrylamide (NIPAM). The effect of mass ratio of NIPAM to KGM on the properties of KGM/P(NIPAM-CA) hydrogels was studied by a range of testing methods. The drug loading and release properties of KGM/P(NIPAM-CA) hydrogel were investigated using 5-fluorouracil (5-FU) as a model drug. Results show that KGM/P(NIPAM-CA) exhibits good swelling and mechanical properties determined by its composition. As a drug carrier KGM/P(NIPAM-CA) hydrogel demonstrated a maximum encapsulation efficiency of 30.17% and a maximum drug loading capacity of 54.41% for 5-FU at 25°C. In simulated colonic fluid (SCF) at 25°C, the cumulative drug release rate of KGM/P(NIPAM-CA) reached 58.86% within 48 hours, which was 1.8 times higher than that in simulated gastric fluid (SGF). Furthermore, the hydrogel demonstrated biocompatibility, with a hemolysis rate of less than 3% and a cell viability exceeding 90%. These results establish KGM/P(NIPAM-CA) as a promising, biocompatible platform for stimuli-responsive, colon-targeted drug delivery.

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魔芋葡甘露聚糖/P（n -异丙基丙烯酰胺-巴豆酸）水凝胶的制备及性能研究

以天然多糖魔芋葡甘露聚糖（KGM）、pH敏感单体巴豆酸（CA）和温度敏感单体n -异丙基丙烯酰胺（NIPAM）为原料，制备了pH和温度双响应的KGM/P（NIPAM）水凝胶药物载体。通过一系列测试方法研究了NIPAM与KGM的质量比对KGM/P（NIPAM- ca）水凝胶性能的影响。以5-氟尿嘧啶（5-FU）为模型药物，研究了KGM/P（NIPAM-CA）水凝胶的载药和释药性能。结果表明：KGM/P（NIPAM-CA）具有良好的溶胀性能和由其组成决定的力学性能。作为药物载体，KGM/P（NIPAM-CA）水凝胶在25℃条件下的包封效率最高为30.17%，5-FU的最大载药量为54.41%。在25℃的模拟结肠液（SCF）中，KGM/P（NIPAM-CA）在48 h内的累积药物释放率达到58.86%，是模拟胃液（SGF）的1.8倍。此外，水凝胶表现出生物相容性，溶血率小于3%，细胞存活率超过90%。这些结果表明KGM/P（NIPAM-CA）是一种有前景的、生物相容性的刺激反应性、结肠靶向药物递送平台。

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来源期刊

Polymer 化学-高分子科学

CiteScore

7.90

自引率

8.70%

发文量

959

审稿时长

32 days

期刊介绍： Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics. The main scope is covered but not limited to the following core areas: Polymer Materials Nanocomposites and hybrid nanomaterials Polymer blends, films, fibres, networks and porous materials Physical Characterization Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films Polymer Engineering Advanced multiscale processing methods Polymer Synthesis, Modification and Self-assembly Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization Technological Applications Polymers for energy generation and storage Polymer membranes for separation technology Polymers for opto- and microelectronics.