When granulomatous inflammation becomes visible: insights into cutaneous sarcoidosis

IF 5.8 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-10-04 DOI:10.1016/j.coi.2025.102673

Mariam Alam , Avrom S. Caplan , Misha Rosenbach

引用次数: 0

Abstract

Cutaneous involvement of sarcoidosis can provide important insights into the presence and prognosis of systemic involvement. Recent insights into the underlying pathophysiology of sarcoidosis have allowed for more targeted therapy, including inhibition of the JAK-STAT and mTOR pathways. In this review article, we discuss the epidemiology, clinical presentation, and pathophysiology of cutaneous sarcoidosis and delve into both traditional and evolving treatment strategies, with a focus on the association of therapy with our evolving understanding of sarcoidosis pathophysiology.

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当可见肉芽肿性炎症时：观察皮肤结节病。

结节病的皮肤受累可以为系统性受累的存在和预后提供重要的见解。最近对结节病的潜在病理生理学的深入研究使得更有针对性的治疗成为可能，包括抑制JAK-STAT和mTOR通路。在这篇综述文章中，我们讨论了皮肤结节病的流行病学、临床表现和病理生理，并深入探讨了传统和新兴的治疗策略，重点是治疗与我们对结节病病理生理的不断发展的理解之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

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