Association of HLA-B and HLA-DR gene polymorphisms with rheumatoid arthritis: A cross-sectional study in Yunnan Chinese Han population.

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Rheumatology and immunology research Pub Date : 2025-10-04 eCollection Date: 2025-09-01 DOI:10.1515/rir-2025-0022

Jing Dong, Yifan Yang, Minghuang Mo, Shuang Liu, Ru Bai, Shu Li, Ruotong Zhao, Xinyu Xu, Yuqi Cheng, Jian Xu

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Abstract

Objectives: To investigate the association between HLA-B and HLA-DR gene polymorphisms and rheumatoid arthritis (RA) in Yunnan Han population, China.

Methods: A total of 246 RA patients and 259 healthy controls (HCs) were enrolled. HLA-B/DR genotyping was performed using high-resolution reverse polymerase chain reaction sequence specific oligonucleotide probe (PCR-SSOP). and serum anti cyclic citrullinated peptide (anti-CCP) antibody and serological indexes were detected.

Results: In RA patients, the allele frequencies of HLA-DRB1*04:05:01, *04:10:01, *10:01:02 and HLA-B*15:01:01G, *40:01:01G, *40:02:01G, and *54:01:01G were significantly higher than those in the HCs (OR > 1, all P < 0.05). Conversely, the frequencies of HLA-DRB1*07:01:01, *14:01:01, *15:01:01:01 and HLA-B*15:01:01, *15:02:01, and *38:02:01 alleles were decreased in RA group (OR < 1, all P < 0.05). Haplotype analysis showed that the combination of HLA-B*15:01/DRB1*09:01, HLA-B*38:02/DRB1*08:03 and HLA-B*54:01/DRB1*04:05 was decreased in RA patients (OR < 1, all P < 0.05).

Conclusions: The susceptibility of RA in Yunnan Han population is closely related to HLA-B/DR specific alleles and haplotypes.

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HLA-B和HLA-DR基因多态性与类风湿关节炎的关联：云南汉族人群的横断面研究

目的：探讨云南省汉族人群HLA-B和HLA-DR基因多态性与类风湿关节炎（RA）的关系。方法：共纳入246例RA患者和259例健康对照（hc）。采用高分辨率反聚合酶链反应序列特异性寡核苷酸探针（PCR-SSOP）进行HLA-B/DR基因分型。血清抗环瓜氨酸肽（anti- ccp）抗体及血清学指标检测。结果：RA患者HLA-DRB1*04:05:01、*04:10:01、*10:01:02和HLA-B*15:01:01G、*40:01:01G、*40:02:01G、*54:01:01G的等位基因频率均显著高于hcc患者（P < 0.05）。相反，RA组HLA-DRB1*07:01:01、*14:01:01、*15:01:01和HLA-B*15:01:01、*15:02:01、*38:02:01等位基因频率降低（OR < 1，均P < 0.05）。单倍型分析显示，RA患者HLA-B*15:01/DRB1*09:01、HLA-B*38:02/DRB1*08:03、HLA-B*54:01/DRB1*04:05的组合降低（OR < 1，均P < 0.05）。结论：云南汉族人群RA易感性与HLA-B/DR特异性等位基因和单倍型密切相关。

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来源期刊

Rheumatology and immunology research

CiteScore

1.40

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0.00%

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