Adverse Childhood Experiences, Depression and Subjective Cognitive Decline by Gender: A Moderated Mediation Analysis.

IF 2 3区医学 Q2 GERONTOLOGY

Journal of Applied Gerontology Pub Date : 2025-10-06 DOI:10.1177/07334648251386108

Monique J Brown, Darlingtina K Esiaka, Jaya Viswanathan

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引用次数: 0

Abstract

Studies assessing depression as a mediating factor between adverse childhood experiences (ACEs) and subjective cognitive decline (SCD) are lacking. Therefore, the aims of this study were to: (1) determine the mediating role of depression in the association between ACEs and SCD; and (2) assess the moderating role of gender. Data were obtained from the 2023 Behavioral Risk Factor Surveillance Study (BRFSS) survey (N = 38,600). Crude and adjusted path analyses were used to determine the mediating role of depression between ACEs and SCD. Adjusted analyses controlled for sociodemographic confounders. ACEs were positively associated with depression (B = 0.129, p < 0.001), depression was positively associated with SCD (B = 0.224, p < 0.001), and ACEs were positively associated with SCD (B = 0.066, p < 0.001). Depression mediated the association between ACEs and SCD in the overall population (B = 0.029, p < 0.001), and for men (B = 0.025, p < 0.001) and women (B = 0.032, p < 0.001). Intervention programs addressing ACEs may reduce depression and help with cognition for men and women.

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童年不良经历、抑郁与主观认知衰退的性别差异：一个有调节的中介分析。

评估抑郁作为不良童年经历（ace）和主观认知衰退（SCD）之间的中介因素的研究缺乏。因此，本研究的目的是：(1)确定抑郁在ace与SCD的关联中的中介作用；(2)评估性别的调节作用。数据来自2023年行为风险因素监测研究（BRFSS）调查（N = 38,600）。采用粗通径和调整通径分析来确定抑郁在ace和SCD之间的中介作用。校正分析控制了社会人口混杂因素。ace与抑郁呈正相关（B = 0.129, p < 0.001），抑郁与SCD呈正相关（B = 0.224, p < 0.001）， ace与SCD呈正相关（B = 0.066, p < 0.001）。抑郁介导了ace和SCD在总体人群中的关联（B = 0.029, p < 0.001），以及男性（B = 0.025, p < 0.001）和女性（B = 0.032, p < 0.001）。针对ace的干预计划可能会减少抑郁症，并有助于男性和女性的认知能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Gerontology GERONTOLOGY-

CiteScore

5.10

自引率

13.30%

发文量

202

期刊介绍： The Journal of Applied Gerontology (JAG) is the official journal of the Southern Gerontological Society. It features articles that focus on research applications intended to improve the quality of life of older persons or to enhance our understanding of age-related issues that will eventually lead to such outcomes. We construe application broadly and encourage contributions across a range of applications toward those foci, including interventions, methodology, policy, and theory. Manuscripts from all disciplines represented in gerontology are welcome. Because the circulation and intended audience of JAG is global, contributions from international authors are encouraged.