Emmanuelle Balme, Bernd Baier, Katja Hempel, Susanne Mueller, Sydney Mukaratirwa, Thomas Nolte
{"title":"Microscopic Findings in Seminal Vesicles of Control Rats Mated to Females From Fertility and Early Embryonic Development Studies.","authors":"Emmanuelle Balme, Bernd Baier, Katja Hempel, Susanne Mueller, Sydney Mukaratirwa, Thomas Nolte","doi":"10.1177/01926233251375447","DOIUrl":null,"url":null,"abstract":"<p><p>Male reproductive organs are rarely examined microscopically in developmental and reproductive toxicity (DART) studies. Therefore, few background histopathological data exist for breeding animals. Yet, toxicologic pathologists must be able to recognize spontaneous lesions in a particular organ or tissue so that these changes are not incorrectly attributed to the test item. Inflammation of the secondary sex organs is described as a common background finding in laboratory rats and mice. Breeding activity may increase the risk of infection of the male accessory glands. In the present communication, we report microscopic changes in seminal vesicles observed in Control rats mated to Control females from three fertility and early embryonic development (FEED) studies. Acute inflammation, inflammatory cell infiltrate, hypertrophy, and increased apoptosis of the glandular epithelium were frequent findings.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"1926233251375447"},"PeriodicalIF":1.8000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicologic Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/01926233251375447","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Male reproductive organs are rarely examined microscopically in developmental and reproductive toxicity (DART) studies. Therefore, few background histopathological data exist for breeding animals. Yet, toxicologic pathologists must be able to recognize spontaneous lesions in a particular organ or tissue so that these changes are not incorrectly attributed to the test item. Inflammation of the secondary sex organs is described as a common background finding in laboratory rats and mice. Breeding activity may increase the risk of infection of the male accessory glands. In the present communication, we report microscopic changes in seminal vesicles observed in Control rats mated to Control females from three fertility and early embryonic development (FEED) studies. Acute inflammation, inflammatory cell infiltrate, hypertrophy, and increased apoptosis of the glandular epithelium were frequent findings.
期刊介绍：
Toxicologic Pathology is dedicated to the promotion of human, animal, and environmental health through the dissemination of knowledge, techniques, and guidelines to enhance the understanding and practice of toxicologic pathology. Toxicologic Pathology, the official journal of the Society of Toxicologic Pathology, will publish Original Research Articles, Symposium Articles, Review Articles, Meeting Reports, New Techniques, and Position Papers that are relevant to toxicologic pathology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
