Short and long-term outcomes in neonatal hypoxic-ischemic encephalopathy treated with hypothermia and vasoactive medications.

IF 2 4区医学 Q2 PEDIATRICS

Paediatrics & child health Pub Date : 2025-05-08 eCollection Date: 2025-09-01 DOI:10.1093/pch/pxaf029

Telford Yeung, Ali Al Sawai, Sharifa Habib, Diane Wilson, Vann Chau, Bonny Jasani, Amr El Shahed

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引用次数: 0

Abstract

Background: Hemodynamic instability in neonatal hypoxic-ischemic encephalopathy (HIE) can contribute to brain injury but long-term neurodevelopmental data is limited. Our objective was to compare the effect of hemodynamic instability requiring vasoactive support on radiologic brain injury and neurodevelopmental outcomes in HIE with therapeutic hypothermia (TH).

Methods: This retrospective cohort study compared infants with HIE post-TH who did not require (Group I) versus those who required vasoactive medications (Group II). The association between hemodynamic instability and MRI brain injury or Bayley Scales of Infant Development III (BSID-III) was evaluated by logistic regression.

Results: Among 185 infants, group II had higher adjusted odds of moderate-severe grey matter injury [odds ratio 5.54; 95% confidence interval 1.70 - 18.05; p < 0.001] than group I, with no differences in adjusted 18-24-month BSID-III scores.

Conclusion: Hemodynamic instability requiring vasoactive support in HIE with TH was associated with higher odds of radiologic brain injury but no difference in neurodevelopmental outcomes.

查看原文本刊更多论文

低温和血管活性药物治疗新生儿缺氧缺血性脑病的短期和长期结果

背景：新生儿缺氧缺血性脑病（HIE）的血流动力学不稳定可导致脑损伤，但长期神经发育数据有限。我们的目的是比较需要血管活性支持的血流动力学不稳定对放射学脑损伤和治疗性低温（TH）的HIE神经发育结局的影响。方法：这项回顾性队列研究比较了不需要（I组）和需要血管活性药物（II组）的th后HIE婴儿。血流动力学不稳定与MRI脑损伤或Bayley婴儿发育量表III （BSID-III）之间的关系通过logistic回归进行评估。结果：185名婴儿中，II组有较高的中重度灰质损伤调整几率[比值比5.54；95%置信区间1.70 - 18.05；结论：HIE合并TH患者需要血管活性支持的血流动力学不稳定与放射学脑损伤的可能性较高相关，但在神经发育结局方面没有差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Paediatrics & child health 医学-小儿科

CiteScore

2.10

自引率

5.30%

发文量

208

审稿时长

>12 weeks

期刊介绍： Paediatrics & Child Health (PCH) is the official journal of the Canadian Paediatric Society, and the only peer-reviewed paediatric journal in Canada. Its mission is to advocate for the health and well-being of all Canadian children and youth and to educate child and youth health professionals across the country. PCH reaches 8,000 paediatricians, family physicians and other child and youth health professionals, as well as ministers and officials in various levels of government who are involved with child and youth health policy in Canada.