D-Allulose Improves Mitochondrial Respiratory Function and Alleviates Obesity-Induced Liver Dysfunction: A Comparative Study with Erythritol in HFD-Fed Mice.

Abstract

This study investigated the anti-obesity and anti-inflammatory effects of D-Allulose compared to erythritol in high-fat diet (HFD)-fed mice, focusing on liver mitochondrial function. Both D-Allulose and erythritol significantly reduced body weight gain, white adipose tissue (WAT) weight, and plasma lipid levels. D-Allulose, especially at higher doses (H_AL), demonstrated superior effects, including reductions in visceral and total WAT weight, adipocyte size, and hepatic and WAT fibrosis, compared to erythritol. D-Allulose also significantly enhanced mitochondrial function, as shown by increased expression of genes and proteins related to lipolysis and oxidative phosphorylation, which were not observed in the erythritol group. Gene expression analysis revealed that D-Allulose more effectively restored HFD-altered gene expression, suggesting stronger regulation of obesity-induced metabolic and inflammatory processes. These findings highlight D-Allulose as a functional sweetener with superior anti-obesity and anti-inflammatory effects, primarily through improved mitochondrial function and modulation of immune and metabolic responses.