Clinical Improvement in a Case of Alternating Hemiplegia of Childhood After Cerebral Lymphatic Drainage.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2025-09-29 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S532665
Sandro Mandolesi, Tarcisio Niglio, Michela Stagnaro, Elisa De Grandis
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引用次数: 0

Abstract

Alternating hemiplegia of childhood (AHC) is a rare neurological disorder characterized by recurrent episodes of hemiplegia and dystonia, significantly affecting patients' quality of life. This exploratory study evaluated the effects of the Muscular Acoustic Modulator (MAM) on a single patient with AHC treated for one year. The treatment was associated with a notable reduction in the frequency and duration of hemiplegic and dystonic episodes, with partial and total hemiplegic episodes decreasing by 52% and 85%, respectively, and partial dystonic episodes decreasing by 81%. Additionally, improvements in behavioural symptoms such as anger and strength outbursts were observed. We hypothesize that MAM treatment could modulate cerebrospinal fluid dynamics and enhance glymphatic drainage, potentially offering a new therapeutic approach for AHC and other neurodegenerative diseases. However, the study's limitations, including the single-patient design, necessitate further research to confirm these preliminary results and elucidate the underlying mechanisms.

Abstract Image

Abstract Image

Abstract Image

脑淋巴引流术后儿童交替性偏瘫1例的临床改善。
儿童交替性偏瘫(AHC)是一种罕见的神经系统疾病,以反复发作的偏瘫和肌张力障碍为特征,严重影响患者的生活质量。本探索性研究评估了肌声调节剂(MAM)对单个AHC患者治疗一年的效果。治疗显著减少了偏瘫和肌张力障碍发作的频率和持续时间,部分和全部偏瘫发作分别减少了52%和85%,部分肌张力障碍发作减少了81%。此外,还观察到愤怒和力量爆发等行为症状的改善。我们假设MAM治疗可以调节脑脊液动力学并增强淋巴引流,可能为AHC和其他神经退行性疾病提供新的治疗方法。然而,该研究的局限性,包括单患者设计,需要进一步的研究来证实这些初步结果并阐明潜在的机制。
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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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