Li Liu, Huixian Kang, Xuli Li, Hairong Yao, Dongmei Shi, Yongjie Liu
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引用次数: 0
Abstract
Purpose: To investigate the association between vitamin D receptor (VDR) gene polymorphisms and sub-clinical hypothyroidism (SCH) risk in polycystic ovary syndrome (PCOS) patients.
Methods: Forty-four PCOS patients and 24 controls were enrolled. VDR gene sequences, lipid profiles, and thyroid function were analyzed, with stratification by SCH status for group comparisons.
Results: PCOS patients showed significant differences in fasting glucose, triglycerides, and BMI vs. controls. SCH patients exhibited distinct Apa I genotypes (P < 0.05), with the AC genotype rate (76.47%) significantly higher in PCOS + SCH vs. other groups. Unadjusted/adjusted ORs for SCH patients with the AC genotype were 4.2 (95% CI 1.40-13.10), 5.01 (95% CI 1.53-16.38), and 6.25 (95% CI 1.69-23.09). No other polymorphisms were significant.
Conclusion: This study revealed that the VDR Apa I genotype (AC as a distinct risk factor) was associated with SCH in PCOS patients, suggesting new genetic insights.
目的：探讨多囊卵巢综合征（PCOS）患者维生素D受体（VDR）基因多态性与亚临床甲状腺功能减退（SCH）风险的关系。方法：纳入44例PCOS患者和24例对照组。分析VDR基因序列、脂质谱和甲状腺功能，并按SCH状态分层进行组间比较。结果：多囊卵巢综合征患者在空腹血糖、甘油三酯和BMI方面与对照组有显著差异。结论：本研究揭示了VDR Apa I基因型（AC作为一个独特的危险因素）与PCOS患者SCH相关，为PCOS患者提供了新的遗传学见解。
期刊介绍：
Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
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