Marco Tabbì, Domenico Fugazzotto, Chiara Caterino, Simone Minniti, Valeria Toneatti, Giuseppe Barillaro, Simone Minato, Claudia Giannetto, Gerardo Fatone, Francesco Macrì
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引用次数: 0
Abstract
Prosencephalic brain tumors (PBTs) are frequently associated with epileptic seizure in dogs, yet the incidence and characteristics of brain herniations (BHs) in this context remain poorly described. This multicentre retrospective study aimed to evaluate the incidence and distribution of BHs and other associated MRI findings in 80 dogs presenting with epileptic seizures secondary to PBTs. MRI studies were assessed for peritumoral edema, lateral ventricular compression, midline shift (MS), subfalcine herniation (SH), caudal transtentorial herniation (CTH), foramen magnum herniation (FMH), and displacement of the quadrigeminal lamina (DQL). Peritumoral edema and lateral ventricular compression were observed in 85 and 77.5% of cases, respectively. MS was observed in 87.5% of cases. SH and CTH were the most common BHs, present in over 75 and 31% of cases, respectively. DQL was observed in 57% of cases, including dogs with tumors anatomically distant from the midbrain. Although tumor volume did not significantly differ between groups, larger lesions were positively correlated with the presence of edema, lateral ventricular compression and laminar displacement. These findings demonstrate that MRI features reflecting mass effect-particularly peritumoral edema, MS, and specific types of BHs-are highly prevalent in dogs with seizure-associated PBTs and may contribute to epileptic seizures generation. The MRI features identified in this study may have prognostic value for potential epileptic seizures development, and should therefore be considered during the clinical evaluation of affected dogs.
期刊介绍:
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.