Peritumoral MRI findings and brain herniations in epileptic dogs with prosencephalic brain tumors: a multicentre retrospective study.

IF 2.9 2区 农林科学 Q1 VETERINARY SCIENCES
Frontiers in Veterinary Science Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI:10.3389/fvets.2025.1661131
Marco Tabbì, Domenico Fugazzotto, Chiara Caterino, Simone Minniti, Valeria Toneatti, Giuseppe Barillaro, Simone Minato, Claudia Giannetto, Gerardo Fatone, Francesco Macrì
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Abstract

Prosencephalic brain tumors (PBTs) are frequently associated with epileptic seizure in dogs, yet the incidence and characteristics of brain herniations (BHs) in this context remain poorly described. This multicentre retrospective study aimed to evaluate the incidence and distribution of BHs and other associated MRI findings in 80 dogs presenting with epileptic seizures secondary to PBTs. MRI studies were assessed for peritumoral edema, lateral ventricular compression, midline shift (MS), subfalcine herniation (SH), caudal transtentorial herniation (CTH), foramen magnum herniation (FMH), and displacement of the quadrigeminal lamina (DQL). Peritumoral edema and lateral ventricular compression were observed in 85 and 77.5% of cases, respectively. MS was observed in 87.5% of cases. SH and CTH were the most common BHs, present in over 75 and 31% of cases, respectively. DQL was observed in 57% of cases, including dogs with tumors anatomically distant from the midbrain. Although tumor volume did not significantly differ between groups, larger lesions were positively correlated with the presence of edema, lateral ventricular compression and laminar displacement. These findings demonstrate that MRI features reflecting mass effect-particularly peritumoral edema, MS, and specific types of BHs-are highly prevalent in dogs with seizure-associated PBTs and may contribute to epileptic seizures generation. The MRI features identified in this study may have prognostic value for potential epileptic seizures development, and should therefore be considered during the clinical evaluation of affected dogs.

脑前脑肿瘤的癫痫犬的瘤周MRI表现和脑疝:一项多中心回顾性研究。
前脑脑瘤(pbt)通常与犬的癫痫发作有关,但在这种情况下,脑疝(BHs)的发生率和特征仍然缺乏描述。这项多中心回顾性研究旨在评估80只继发于pbt的癫痫发作犬BHs的发生率和分布以及其他相关MRI发现。MRI检查评估肿瘤周围水肿、侧室压迫、中线移位(MS)、镰下疝(SH)、尾侧幕下疝(CTH)、枕骨大孔疝(FMH)和四叉肌板移位(DQL)。肿瘤周围水肿占85%,侧室受压占77.5%。87.5%的病例出现多发性硬化症。SH和CTH是最常见的BHs,分别占超过75%和31%的病例。在57%的病例中观察到DQL,包括解剖上远离中脑的肿瘤的狗。虽然肿瘤体积在两组间无显著差异,但较大的病变与水肿、侧心室压迫和层压板移位呈正相关。这些发现表明,反映肿块效应的MRI特征——特别是肿瘤周围水肿、MS和特定类型的bhs——在癫痫相关pbt犬中非常普遍,并可能导致癫痫发作。本研究中发现的MRI特征可能对潜在的癫痫发作发展具有预后价值,因此在对患病犬进行临床评估时应予以考虑。
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来源期刊
Frontiers in Veterinary Science
Frontiers in Veterinary Science Veterinary-General Veterinary
CiteScore
4.80
自引率
9.40%
发文量
1870
审稿时长
14 weeks
期刊介绍: Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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