{"title":"The predictive value of neutrophil to lymphocyte ratio for abortion: a systematic review and meta-analysis.","authors":"Mi Wang, Rui Yue, Jun Xi, Fang Yan","doi":"10.3389/fmed.2025.1565979","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Abortion usually refers to the loss of pregnancy before viability. Despite a potential link between neutrophil-lymphocyte ratio (NLR) levels and abortion, inconclusive findings remain. This review aimed to comprehensively appraise the predictive utility of NLR levels in abortion, offering a new approach to clarify its potential role as a biomarker.</p><p><strong>Methods: </strong>PubMed and Cochrane Library were searched for relevant cohort and case-control studies until September 2024. Odds ratio (OR) or weighted mean difference (WMD) with 95% CI of abortion were computed. Subgroup analyses were implemented to clarify potential sources of heterogeneity.</p><p><strong>Results: </strong>Higher NLR levels were linked to an enhanced risk of abortion as a continuous (WMD, 0.58; 95% CI: 0.29, 0.88) and dichotomous variable (OR, 1.33; 95% CI: 1.03, 1.72). In subgroup analyses, pooled results from studies with NLR cut-off>3, Asia populations, missed abortion, spontaneous abortion, and mean age>30 demonstrated an increased risk of abortion. In continuous NLR for predicting abortion, retrospective study, Europe populations, threatened abortion, recurrent pregnancy loss, and abortion had an enhanced risk of abortion for higher NLR levels as a dichotomous variable.</p><p><strong>Conclusion: </strong>Pooled analyses demonstrated that higher NLR levels may predict abortion. Further investigations need to determine whether these findings can be generalized to all populations.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/485726.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1565979"},"PeriodicalIF":3.1000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491316/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1565979","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Abortion usually refers to the loss of pregnancy before viability. Despite a potential link between neutrophil-lymphocyte ratio (NLR) levels and abortion, inconclusive findings remain. This review aimed to comprehensively appraise the predictive utility of NLR levels in abortion, offering a new approach to clarify its potential role as a biomarker.
Methods: PubMed and Cochrane Library were searched for relevant cohort and case-control studies until September 2024. Odds ratio (OR) or weighted mean difference (WMD) with 95% CI of abortion were computed. Subgroup analyses were implemented to clarify potential sources of heterogeneity.
Results: Higher NLR levels were linked to an enhanced risk of abortion as a continuous (WMD, 0.58; 95% CI: 0.29, 0.88) and dichotomous variable (OR, 1.33; 95% CI: 1.03, 1.72). In subgroup analyses, pooled results from studies with NLR cut-off>3, Asia populations, missed abortion, spontaneous abortion, and mean age>30 demonstrated an increased risk of abortion. In continuous NLR for predicting abortion, retrospective study, Europe populations, threatened abortion, recurrent pregnancy loss, and abortion had an enhanced risk of abortion for higher NLR levels as a dichotomous variable.
Conclusion: Pooled analyses demonstrated that higher NLR levels may predict abortion. Further investigations need to determine whether these findings can be generalized to all populations.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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