Association between obesity at age 20 and postpartum glucose tolerance in women with a history of gestational diabetes mellitus

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-10-03 DOI:10.1016/j.diabres.2025.112930

Akiho Yamashita , Masayuki Kaku , Marina Matsunaga , Satomi Inoue , Koichi Arizono , Takuya Ideguchi , Takuro Watanabe , Shuhei Nishida , Takeshi Nishikawa

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Abstract

Aims

We aimed to investigate the association between obesity at age 20 and weight gain from age 20 to pregnancy and postpartum glucose tolerance in women with a history of gestational diabetes mellitus (GDM).

Methods

This retrospective cohort study included 433 patients with GDM who underwent prenatal glycemic control and a 75-g oral glucose tolerance test 6 to 12 weeks after delivery. The independent factors, adjusted risk ratios (aRR), and 95 % confidence intervals (CI) were calculated using multivariable Poisson regression with robust variance.

Results

Obesity at age 20 was an independent predictor for the onset of postpartum impaired glucose tolerance (IGT) and diabetes mellitus (DM) (aRR: 1.726, 95 % CI: 1.217–2.446) and postpartum insulin resistance (aRR: 1.532, 95 % CI: 1.085–2.164). Weight gain from age 20 to pregnancy was an independent predictor for the onset of postpartum insulin resistance (aRR: 1.050, 95 % CI: 1.024–1.077). Furthermore, the aRR for the onset of postpartum IGT and DM in the obesity at age 20, pre-pregnancy, and postpartum group was significantly higher than the no history of obesity group (aRR: 2.104, 95 % CI: 1.390–3.185).

Conclusions

Japanese women need to maintain a normal weight from age 20 to prevent the onset of DM.

Abstract Image

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妊娠糖尿病史妇女20岁肥胖与产后糖耐量的关系

目的：研究有妊娠期糖尿病（GDM）病史的女性20岁时肥胖与20岁至妊娠期体重增加及产后糖耐量之间的关系。方法：本回顾性队列研究纳入433例GDM患者，这些患者在分娩后6至12 周进行产前血糖控制和75 g口服葡萄糖耐量试验。独立因素、校正风险比（aRR）和95% %置信区间（CI）采用稳健方差的多变量泊松回归计算。结果：20岁肥胖是产后糖耐量受损（IGT）和糖尿病（DM）发病的独立预测因子（aRR: 1.726, 95% CI: 1.117 -2.446）和产后胰岛素抵抗（aRR: 1.532, 95% CI: 1.085-2.164）。20岁至妊娠期间体重增加是产后胰岛素抵抗发生的独立预测因子（aRR: 1.050, 95% CI: 1.024-1.077）。20岁肥胖组、孕前肥胖组和产后肥胖组发生产后IGT和DM的aRR显著高于无肥胖史组（aRR: 2.104, 95% CI: 1.390 ~ 3.185）。结论：日本女性需要从20岁开始保持正常体重以预防糖尿病的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.