Incidence and risk factors of venous thromboembolism following radical nephrectomy: A meta-analysis of observational studies.

IF 1.2 Q3 UROLOGY & NEPHROLOGY

Arab Journal of Urology Pub Date : 2025-01-26 eCollection Date: 2025-01-01 DOI:10.1080/20905998.2025.2457923

Yuan Li, Chiming Gu, Siyi Li, Franky Leung Chan, Shusheng Wang

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引用次数: 0

Abstract

Background: A meta-analysis was conducted to evaluate the incidence of venous thromboembolism (VTE) following radical nephrectomy and to examine the related risk factors.

Methods: We conducted a comprehensive search for primary research articles from the inception of the databases up to October, 2024 across several databases, including MEDLINE, Embase, and the Cochrane Library. We employed random effects models to determine multivariate adjusted odds ratios (ORs) along with their corresponding 95% confidence intervals (CIs).

Results: In total, 11 studies including 140,795 patients who underwent radical nephrectomy met inclusion criteria. The results showed that postoperative VTE incidence was 1.01% (95% CI = 1.01-1.02; p < 0.001) within 30 days. Moreover, diabetes, open nephrectomy, and history of VTE were related to higher odds of VTE through regression analysis. Analyses of sensitivity and meta-regression demonstrated the robustness of the study's findings.

Conclusions: The overall incidence of VTE after radical nephrectomy is 1%, occurring approximately one month after surgery, and may be related to factors such as open surgery, diabetes and history of VTE. This reminds urologists that more aggressive thromboprophylaxis may be required for these patients.

Prospero registration number: CRD42023439919.

查看原文本刊更多论文

根治性肾切除术后静脉血栓栓塞的发生率和危险因素：观察性研究的荟萃分析。

背景：进行了一项荟萃分析，以评估根治性肾切除术后静脉血栓栓塞（VTE）的发生率，并检查相关危险因素。方法：我们在MEDLINE、Embase和Cochrane图书馆等多个数据库中对从数据库建立到2024年10月的主要研究文章进行了全面检索。我们采用随机效应模型来确定多变量调整比值比（ORs）及其相应的95%置信区间（ci）。结果：总共有11项研究包括140,795例接受根治性肾切除术的患者符合纳入标准。结论：根治性肾切除术后静脉血栓栓塞发生率总体为1%，发生时间约为术后1个月，可能与开放性手术、糖尿病、静脉血栓栓塞史等因素有关。这提醒泌尿科医生，这些患者可能需要更积极的血栓预防。普洛斯彼罗注册号：CRD42023439919。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arab Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： The Arab Journal of Urology is a peer-reviewed journal that strives to provide a high standard of research and clinical material to the widest possible urological community worldwide. The journal encompasses all aspects of urology including: urological oncology, urological reconstructive surgery, urodynamics, female urology, pediatric urology, endourology, transplantation, erectile dysfunction, and urinary infections and inflammations. The journal provides reviews, original articles, editorials, surgical techniques, cases reports and correspondence. Urologists, oncologists, pathologists, radiologists and scientists are invited to submit their contributions to make the Arab Journal of Urology a viable international forum for the practical, timely and state-of-the-art clinical urology and basic urological research.