Khoirul Husam, Purwita Wijaya Laksmi, Robert Sinto, Andhika Rachman, Rudy Hidayat, Sukamto Koesnoe, Noto Dwimartutie, Dyah Purnamasari
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引用次数: 0
Abstract
Background: Type 2 Diabetes Mellitus (T2DM) in young adults is associated with an increased risk of early sarcopenia due to insulin resistance and inflammation. This insulin resistance and inflammation can be influenced by leptin and adiponectin, which are key adipocytokines produced by adipose cells. However, no studies have examined the relationship between leptin, adiponectin levels, and sarcopenia in T2DM patients under 60 years old. This study aimed to investigate the relationship between leptin, adiponectin levels, and Leptin-to-Adiponectin ratio (LAR) with sarcopenia in non-geriatric T2DM patients.
Methods: This cross-sectional study was conducted from January 2021 to April 2022. The subjects consisted of T2DM patients aged 18-59 years at Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Baseline data were sourced from a primary study, while stored serum samples were analyzed for leptin and adiponectin using ELISA. Leptin and adiponectin differences were assessed statistically using the Mann-Whitney U test, and the Kruskal-Wallis test was used for additional analysis.
Results: Among 97 subjects, 4 (4.1%) had sarcopenia, while 34 out of 93 non-sarcopenic subjects belonged to the possible sarcopenia category. Bivariate analysis results showed significant differences between leptin levels (p=0.005) and the Leptin-to-Adiponectin Ratio (LAR) (p=0.003) with sarcopenia in non-geriatric T2DM patients. Meanwhile, adiponectin levels (p=0.799) did not show statistical differences. Further analysis was conducted among three groups, namely sarcopenia, possible sarcopenia, and non-sarcopenia. The result showed statistically significant differences in leptin and LAR levels between sarcopenia and possible sarcopenia (leptin p=0.004; LAR p=0.007) as well as sarcopenia and non-sarcopenia (leptin p=0.038; LAR p=0.011).
Conclusion: Leptin levels and LAR were associated with sarcopenia in a non-geriatric T2DM population.
背景：年轻人2型糖尿病（T2DM）与胰岛素抵抗和炎症引起的早期肌肉减少症风险增加相关。这种胰岛素抵抗和炎症可受到瘦素和脂联素的影响，这是脂肪细胞产生的关键脂肪细胞因子。然而，没有研究检查60岁以下T2DM患者瘦素、脂联素水平与肌肉减少症之间的关系。本研究旨在探讨非老年T2DM患者瘦素、脂联素水平和瘦素/脂联素比值（LAR）与肌肉减少症的关系。方法：本横断面研究于2021年1月至2022年4月进行。研究对象为印度尼西亚雅加达Cipto Mangunkusumo医院18-59岁的2型糖尿病患者。基线数据来源于一项初步研究，同时使用ELISA分析储存的血清样本中的瘦素和脂联素。使用Mann-Whitney U检验评估瘦素和脂联素的差异，并使用Kruskal-Wallis检验进行附加分析。结果：97例患者中有4例（4.1%）发生肌少症，93例非肌少症患者中有34例属于可能的肌少症类别。双因素分析结果显示，瘦素水平（p=0.005）和瘦素/脂联素比值（LAR） （p=0.003）与非老年T2DM患者肌肉减少症之间存在显著差异。脂联素水平差异无统计学意义（p=0.799）。对肌肉减少症、可能的肌肉减少症和非肌肉减少症三组进行进一步分析。结果显示，瘦素和LAR水平在肌少症和可能的肌少症（leptin p=0.004; LAR p=0.007）以及肌少症和非肌少症（leptin p=0.038; LAR p=0.011）之间有统计学差异。结论：瘦素水平和LAR与非老年T2DM人群的肌肉减少症有关。
期刊介绍：
Acta Medica Indonesiana – The Indonesian Journal of Internal Medicine is an open accessed online journal and comprehensive peer-reviewed medical journal published by the Indonesian Society of Internal Medicine since 1968. Our main mission is to encourage the novel and important science in the clinical area in internal medicine. We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of internal medicine. Subjects suitable for publication include, but are not limited to the following fields of: -Allergy and immunology -Emergency medicine -Cancer and stem cells -Cardiovascular -Endocrinology and Metabolism -Gastroenterology -Gerontology -Hematology -Hepatology -Tropical and Infectious Disease -Virology -Internal medicine -Psychosomatic -Pulmonology -Rheumatology -Renal and Hypertension -Thyroid
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