{"title":"ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS (AGEP) CAUSED BY ANTIBIOTIC POLYTHERAPY: A CASE REPORT.","authors":"Siniša Jolić, Zdenka Šitum Čeprnja, Toni Čeprnja, Ognjen Jolić, Mirna Šitum","doi":"10.20471/acc.2024.63.03-04.48","DOIUrl":null,"url":null,"abstract":"<p><p>Acute generalized exanthematous pustulosis (AGEP) is a rare disease, usually associated with drug intake or infections. It is characterized by generalized acute pustules and non-follicular exanthema together with systemic symptoms. Histologically, it is characterized by a subcorneal intraepidermal spongiform pustule, papillary edema and dermal vasodilatation surrounded by a polymorphous infiltrate of neutrophils, eosinophils and mononuclear cells. The aim of this article is to present current knowledge regarding the etiology and treatment, as well as the clinical and histologic features of AGEP. We present a case of a 50-year-old male patient who was prescribed several antibiotics and developed a drug-related cutaneous adverse effect. Treatment involved rapid identification of the causative agent and its discontinuation together with supportive measures, with resolution of symptoms within two weeks. Early diagnosis and timely treatment result in a favorable outcome and prevent systemic complications.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"834-838"},"PeriodicalIF":0.8000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490489/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta clinica Croatica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.20471/acc.2024.63.03-04.48","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Acute generalized exanthematous pustulosis (AGEP) is a rare disease, usually associated with drug intake or infections. It is characterized by generalized acute pustules and non-follicular exanthema together with systemic symptoms. Histologically, it is characterized by a subcorneal intraepidermal spongiform pustule, papillary edema and dermal vasodilatation surrounded by a polymorphous infiltrate of neutrophils, eosinophils and mononuclear cells. The aim of this article is to present current knowledge regarding the etiology and treatment, as well as the clinical and histologic features of AGEP. We present a case of a 50-year-old male patient who was prescribed several antibiotics and developed a drug-related cutaneous adverse effect. Treatment involved rapid identification of the causative agent and its discontinuation together with supportive measures, with resolution of symptoms within two weeks. Early diagnosis and timely treatment result in a favorable outcome and prevent systemic complications.
期刊介绍：
Acta Clinica Croatica is a peer reviewed general medical journal that publishes original articles that advance and improve medical science and practice and that serve the purpose of transfer of original and valuable information to journal readers. Acta Clinica Croatica is published in English four times a year.
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