Research Advances of Extrachromosomal Circular DNA in Breast Cancer.

IF 3.1 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-10-01 DOI:10.1002/cam4.71285

Xiaodan Zhu, Yiyang Qian, Quan Tang, Jiahui Li, Yuqing Geng, Shixia Gong, Chunhui Jin

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引用次数: 0

Abstract

Background: This article presents an extensive review of the advancements in research concerning extrachromosomal circular DNA (ecDNA) within the context of breast cancer. As a distinct form of DNA, ecDNA is critically involved in the initiation, progression, diagnosis, and treatment of breast cancer.

Methods: The article provides a comprehensive analysis of the mechanisms underlying the formation of ecDNA, highlighting factors such as aberrant DNA damage repair and chromosomal rearrangements. It further examines the biological roles of ecDNA in augmenting oncogene expression, fostering tumor heterogeneity, and facilitating immune evasion.

Results: Epidemiological studies indicate significant variability in the distribution of ecDNA across different breast cancer subtypes, with a notable association with invasive subtypes, such as triple-negative breast cancer. The presence of ecDNA is linked to poor prognosis and treatment resistance in patients. Current detection technologies for ecDNA include molecular biology and imaging techniques, and its detectability in plasma underscores its potential as a biomarker for liquid biopsy.

Conclusions: The development of ecDNA-targeted therapies and their integration with immunotherapy strategies offers promising new avenues for breast cancer treatment. Despite challenges such as incomplete elucidation of mechanisms, standardization of detection methods, and ethical considerations, ecDNA remains a valuable biomarker and therapeutic target in breast cancer. Future research is anticipated to advance its clinical transformation and application in individualized treatment.

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染色体外环状DNA在乳腺癌中的研究进展。

背景：本文介绍了在乳腺癌背景下染色体外环状DNA （ecDNA）的研究进展。作为一种独特的DNA形式，ecDNA在乳腺癌的发生、发展、诊断和治疗中起着至关重要的作用。方法：本文全面分析了ecDNA形成的机制，重点分析了异常DNA损伤修复和染色体重排等因素。它进一步研究了ecDNA在增加癌基因表达、促进肿瘤异质性和促进免疫逃避中的生物学作用。结果：流行病学研究表明，ecDNA在不同乳腺癌亚型中的分布存在显著差异，与侵袭性亚型（如三阴性乳腺癌）有显著相关性。ecDNA的存在与患者预后不良和治疗耐药有关。目前ecDNA的检测技术包括分子生物学和成像技术，其在血浆中的可检测性强调了其作为液体活检生物标志物的潜力。结论：ecdna靶向治疗的发展及其与免疫治疗策略的结合为乳腺癌治疗提供了有希望的新途径。尽管存在机制不完全阐明、检测方法标准化和伦理考虑等挑战，但ecDNA仍然是乳腺癌中有价值的生物标志物和治疗靶点。未来的研究将推动其在个体化治疗中的临床转化和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.