Link between triglyceride-glucose-body mass index and future cardiovascular disease risk in Chinese menopausal women: A nationwide prospective cohort study.

IF 4.3

Experimental gerontology Pub Date : 2025-10-02 DOI:10.1016/j.exger.2025.112906

Daoyuan Wei, Weiqi Zhu, Xinyu Yang, Yuanxiang Liu, Jiguo Yang

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Abstract

Background: The association between the triglyceride glucose-body mass (TyG-BMI) index and cardiovascular disease (CVD) risk in postmenopausal women remains unclear. This study examines this association in Chinese menopausal women to develop targeted risk assessment tools.

Methods: Data from the 2011 and 2020 China Health and Retirement Longitudinal Study (CHARLS) included menopausal women aged ≥45 years. Multivariable logistic regression models assessed the association between TyG-BMI and CVD. Restricted cubic spline (RCS) regression tested nonlinearity, and stratified analyses evaluated effect modification.

Results: Among 2405 participants, 609 (25.32 %) developed CVD. Each interquartile TyG-BMI (49.10) increase raised CVD risk by 28 % (OR = 1.28; 95 % CI: 1.07-1.53). A linear dose-response relationship existed for CVD (P-trend <0.05; P-nonlinearity >0.05). Marital status modified the association (P-interaction = 0.035), with no significant interactions in other subgroups. For CVD prediction, TyG-BMI (AUC = 0.645) outperformed TyG (AUC = 0.622).

Conclusions: Our study demonstrates a significant association between TyG-BMI and the risk of CVD in postmenopausal women, supporting its utility as a valuable biomarker for enhancing primary prevention and management strategies in this population.

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甘油三酯-葡萄糖-体重指数与中国绝经妇女未来心血管疾病风险之间的联系：一项全国性的前瞻性队列研究

背景：绝经后妇女甘油三酯-葡萄糖-体重（TyG-BMI）指数与心血管疾病（CVD）风险之间的关系尚不清楚。本研究考察了中国绝经期妇女的这种关联，以开发有针对性的风险评估工具。方法：数据来自2011年和2020年中国健康与退休纵向研究（CHARLS），包括年龄≥45 岁的绝经妇女。多变量logistic回归模型评估了TyG-BMI与CVD之间的关系。限制三次样条（RCS）回归检验非线性，分层分析评价效果修正。结果：2405名参与者中，609名（25.32% %）发生心血管疾病。TyG-BMI（49.10）每增加1个四分位数，心血管疾病风险增加28 % （OR = 1.28;95 % CI: 1.07-1.53）。CVD存在线性剂量-效应关系（p趋势0.05）。婚姻状况改变了这种关联（P-interaction = 0.035），其他亚组间无显著的相互作用。对于CVD预测，TyG- bmi （AUC = 0.645）优于TyG （AUC = 0.622）。结论：我们的研究表明，TyG-BMI与绝经后妇女心血管疾病风险之间存在显著关联，支持其作为一种有价值的生物标志物，可用于加强该人群的一级预防和管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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