Robertsonian translocation rob(13;19) identified in guinea pig (Cavia porcellus, Rodentia).

IF 1.3 4区生物学 Q4 CELL BIOLOGY

Cytogenetic and Genome Research Pub Date : 2025-10-04 DOI:10.1159/000548825

Halina Cernohorska, Svatava Kubickova, Petra Musilova, Miluse Vozdova

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引用次数: 0

Abstract

Introduction: The domestic guinea pig (Cavia porcellus, Caviidae) is an important laboratory species, model for human medical research, worldwide spread pet and a source of food in specific parts of South America. Data on chromosomal abnormalities in guinea pigs are really limited, probably due to the complexity of their karyotype (2n = 64).

Methods: G-and C-banding and fluorescence in situ hybridization (FISH) using human chromosome-specific painting probes were used to analyse the karyotype and identify chromosomes involved in a newly discovered Robertsonian translocation.

Results: Karyotype 63,XY,rob(13;19) was revealed in a phenotypically normal, fertile domestic guinea pig male. The chromosomes involved in the fusion were verified using FISH with human whole chromosome probes and known guinea pig - human chromosome synteny.

Conclusion: This finding adds to the limited cytogenetic data available on guinea pigs, and provides a basis for further investigation of their chromosomal variation and its biological significance. Our results indicate the need for chromosome studies in this cytogenetically mostly neglected species, especially in breeding populations used for biomedical research.

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在豚鼠（啮齿目Cavia porcellus）中发现Robertsonian易位罗布（13;19）。

简介：国内豚鼠（豚鼠科）是一种重要的实验室物种，是人类医学研究的模型，是世界范围内传播的宠物，也是南美洲特定地区的食物来源。关于豚鼠染色体异常的数据确实有限，可能是由于其核型的复杂性（2n = 64）。方法：利用人类染色体特异性绘画探针，采用g -和c -带和荧光原位杂交（FISH）技术对新发现的Robertsonian易位进行核型分析和染色体鉴定。结果：在一只表型正常、可生育的家养雄性豚鼠中发现了63、XY、rob（13;19）的核型。参与融合的染色体使用FISH与人类全染色体探针和已知的豚鼠-人染色体合群进行验证。结论：这一发现补充了现有豚鼠细胞遗传学资料的不足，为进一步研究豚鼠染色体变异及其生物学意义提供了基础。我们的结果表明，有必要对这种细胞遗传学上大多被忽视的物种进行染色体研究，特别是在用于生物医学研究的育种群体中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytogenetic and Genome Research 生物-细胞生物学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： During the last decades, ''Cytogenetic and Genome Research'' has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are the vast majority of the reports of the International Workshops on Human Chromosome Mapping, the reports of international human and animal chromosome nomenclature committees, and proceedings of the American and European cytogenetic conferences and other events. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.