Nutritional status and surgical outcomes in patients with esophageal atresia: findings from Turkish Esophageal Atresia Registry.

IF 1.6 3区医学 Q2 PEDIATRICS

Pediatric Surgery International Pub Date : 2025-10-04 DOI:10.1007/s00383-025-06216-2

Tutku Soyer, Süleyman Arif Bostancı, Çiğdem Ulukaya Durakbaşa, Coşkun Özcan, İlhan Çiftçi, Gülnur Göllü, Ayşe Parlak, Emine Burcu Ciğşar Kuzu, Berat Dilek Demirel, İbrahim Akkoyun, Binali Fırıncı, Gül Şalcı, Olga Devrim Ayvaz, Akgün Oral, Hüseyin İlhan, Gürsu Kıyan, Ali Ekber Hakalmaz, Ayşe Karaman, Fatma Saraç, Şeref Selçuk Kılıç, Osman Uzunlu, Abdülkerim Temiz, Esra Özçakır, Başak Erginel, Abdullah Yıldız, Ali Onur Erdem, Serpil Sancar, Alev Süzen, Ahmet Atıcı, Seyithan Özaydın, Ebru Yeşildağ, Mehmet Ali Özen, Osman Dağ

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引用次数: 0

Abstract

Purpose: To evaluate the relationship between nutritional status and surgical outcomes in patients with esophageal atresia (EA) from the Turkish Esophageal Atresia Registry (TEAR).

Methods: Between 2015 and 2024, 713 patients with the complete data of neonatal period and first year of life were included. According to FENTON, growth charts and patients were grouped as small for gestational age (SGA, < 10 percentiles), medium SGA (percentiles = 10-20), appropriate for gestational age (AGA, percentiles = 20-90) and large for gestational age (LGA, percentiles > 90) at birth. The z scores for height-for-weight were reevaluated at 6th and 12th months of age.

Results: Among 713 patients, 56% were boys. 23.7% of patients were SGA. There was no difference among groups for demographic features, outcomes, and mortality (p > 0.05). Patients with SGA had a higher rate of karyotype anomalies (23.1%, p < 0.05). At the 6th month, 20% of patients had improved nutritional status, 46.2% unchanged, and 33.5% worsened. At the 12th month, it was 31.6%, 50.2%, and 18.3%, respectively. 32.8% of the SGA patients had severe malnutrition at the 6th month, while this rate decreased to 10.2% at the end of the first year of life. Patients with worsened nutritional status had a significantly higher rate of mortality (10.2%) than patients with unchanged and improved nutritional status (3.7%, 2%, respectively, p < 0.05). There was no statistical difference between nutritional status and surgical outcomes at the 6th and 12th months (p > 0.05).

Conclusions: The incidence of SGA was significantly higher in EA patients with karyotype anomalies. While 20% of patients improved nutritional status at the 6th month, only one-third of patients improved nutritional status at the end of the first year. Closer follow-up is needed in patients with EA to avoid malnutrition, which can lead to poor growth, developmental delay, and impaired immune function.

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食道闭锁患者的营养状况和手术结果：来自土耳其食道闭锁登记处的调查结果。

目的：从土耳其食道闭锁登记（TEAR）中评估食道闭锁（EA）患者营养状况与手术结果的关系。方法：选取2015 - 2024年713例新生儿期及1年生命资料完整的患儿。根据FENTON，生长图表和患者在出生时按胎龄分组（SGA, 90）。在6个月和12个月时重新评估身高体重比z分数。结果：713例患者中，男孩占56%。23.7%的患者为SGA。组间人口学特征、结局和死亡率无差异（p < 0.05）。SGA患者核型异常发生率较高（23.1%,p < 0.05）。结论：核型异常的EA患者中SGA的发生率明显增高。虽然20%的患者在第6个月时营养状况得到改善，但只有三分之一的患者在第一年末营养状况得到改善。EA患者需要更密切的随访，以避免营养不良，营养不良可导致生长不良、发育迟缓和免疫功能受损。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Surgery International 医学-外科

CiteScore

3.00

自引率

5.60%

发文量

215

审稿时长

3-6 weeks

期刊介绍： Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children. The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include: -Review articles- Original articles- Technical innovations- Letters to the editor