Immunological features driving distinct repigmentation patterns in patients with stable vitiligo submitted to the autologous keratinocyte/melanocyte transplantation.

IF 2.8 4区医学 Q3 IMMUNOLOGY

Immunology letters Pub Date : 2025-10-02 DOI:10.1016/j.imlet.2025.107098

Bruna Estefânia Diniz Frias, Roberta Oliveira Prado, Mariana Gontijo Ramos, Nathália Werneck Cézar de Oliveira, Fernanda Fortes de Araújo, Liliane Martins Dos Santos, Camila Gontijo Ramos, Camila Bechara Kallás, Maria Sílvia Laborne Alves de Sousa, Ismael Artur Costa-Rocha, Joaquim Pedro Brito-de-Sousa, Rachel Basques Caligiorne, Marcelo Antônio Pascoal-Xavier, Vanessa Peruhype-Magalhães, Daniel Gontijo Ramos, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho

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引用次数: 0

Abstract

This study aimed to characterize biomarkers of therapeutic response in patients with stable vitiligo undergoing the autologous non-cultured keratinocyte/melanocyte transplantation. The approaches performed were systemic analysis evaluated during pre-transplantation/(D0), seven/(D7), and 28/(D28-45) days after the procedure and compartmentalized analysis in epidermal cell suspension (explant). Increased number of pro-inflammatory monocytes and NK-cells was found during the transplantation follow-up in vitiligo patients compared to the control. There were higher numbers of CD8+ T-cells and CD4+HLA-DR+ T-cells circulating at D28-45 compared to D0, and increased number of CD8+HLA-DR+ T-cells at D28-45 compared to D7. Decreased levels of the most pro-inflammatory chemokines/cytokines during post-transplantation kinetics timeline were observed. Integrative analysis demonstrated that patients with unsatisfactory repigmentation presented higher numbers of connections between the blood/skin components at D0. The data suggest differentiated profiles in the dynamics of the hematological/immunological biomarkers, according to the kinetics timeline and the clinical outcome of repigmentation in vitiligo patients.

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在接受自体角质细胞/黑素细胞移植的稳定型白癜风患者中，免疫特征驱动不同的再色素沉着模式。

本研究旨在描述稳定性白癜风患者接受自体非培养角质细胞/黑素细胞移植治疗反应的生物标志物。所采用的方法是在移植前/(D0)、7 /(D7)和28/(D28-45)天进行系统分析，并在表皮细胞悬液（外植体）中进行区隔分析。与对照组相比，白癜风患者在移植随访期间发现促炎单核细胞和nk细胞数量增加。与D0相比，D28-45时循环的CD8+ t细胞和CD4+HLA-DR+ t细胞数量增加，D28-45时循环的CD8+HLA-DR+ t细胞数量比D7增加。在移植后的动力学时间线中，观察到大多数促炎趋化因子/细胞因子水平下降。综合分析表明，重新着色不满意的患者在D0时血液/皮肤成分之间的连接数量更多。这些数据表明，根据白癜风患者的动力学时间线和临床结果，血液学/免疫学生物标志物的动力学存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.