Microbiome-Based Interventions for Skin Aging and Barrier Function: A Comprehensive Review.

Abstract

The skin microbiome, a dynamic ecosystem of microorganisms, is essential for maintaining skin health by protecting against pathogens, modulating immunity, and enhancing barrier function. External factors such as pollutants, harsh skincare products, and aging disrupt microbial balance, leading to compromised skin health and accelerated aging. Aging-related changes, including reduced microbial diversity, loss of beneficial metabolites, and increased oxidative stress, contribute to inflammaging. Microbiome-supportive skincare, incorporating probiotics, prebiotics, and postbiotics, offers promising solutions to restore microbial balance, strengthen the skin barrier, and delay aging. These formulations work by reducing inflammation, enhancing antioxidant defenses, and regulating skin pH. However, challenges in microbiome research and product development persist, including individual variability in microbial composition, formulation complexities, and a limited understanding of microbe-skin interactions. Future innovations such as personalized microbiome skincare, genetically engineered probiotics, and advanced diagnostic tools could enable more targeted and effective interventions. Long-term clinical trials and detailed mechanistic studies are crucial to validate the efficacy of microbiome-focused skincare and optimize formulations for diverse populations. By addressing these challenges and advancing research, microbiome-supportive skincare has the potential to revolutionize approaches to skin health, preserving resilience and combating aging through tailored microbial interventions.