Maria Garcia-Iruretagoyena, Alejandra Outeiriño-Fernández, Maria Sobrido-Prieto, Amaia Bilbao-González, Alicia González-Mourelle
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引用次数: 0
Abstract
Objectives: To determine the most effective diagnostic imaging modality including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET/CT), and ultrasound (US) for the identification of regional lymph node involvement in patients with oral squamous cell carcinoma (OSCC).
Methods: A search was performed to identify qualified studies using PubMed, Scopus, and Web of Science electronic databases from January 2013 to December 2023. The outcome assessed was the diagnostic performance of different imaging techniques in the detection of cervical lymph node metastasis in OSCC, with lymph node yield in neck dissection specimens as the gold standard for validation. Summary estimates for diagnostic performance were sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence intervals (CIs). Differences in sensitivities, specificities, and DOR were tested using a bivariate random effects model.
Results: Twelve observational studies including PET/CT, MRI, and CT alone or combined in OSCC patients were included in the meta-analysis. Data from a single study based on US were insufficient to assess the value of this imaging modality. The pooled estimates of sensitivity were 0.87 for PET/CT, 0.70 for MRI, and 0.66 for CT. The corresponding pooled specificities were 0.79, 0.79, and 0.81, respectively. The DOR was 24.85 for PET/CT, 8.60 for MRI, and 8.59 for CT.
Conclusion: PET/CT may be recommended in clinical practice for detecting cervical metastatic disease in OSCC patients as this technique showed the most favorable diagnostic performance as compared with MRI and CT.
目的：确定最有效的诊断成像方式，包括计算机断层扫描（CT），磁共振成像（MRI），正电子发射断层扫描-计算机断层扫描（PET/CT）和超声（US），以识别口腔鳞状细胞癌（OSCC）患者的区域淋巴结累及。方法：检索PubMed、Scopus和Web of Science电子数据库中2013年1月至2023年12月的合格研究。评估的结果是不同成像技术在OSCC颈部淋巴结转移检测中的诊断性能，以颈部清扫标本的淋巴结率作为验证的金标准。诊断性能的总结估计是敏感性、特异性和诊断优势比（DOR）， 95%置信区间（ci）。使用双变量随机效应模型检验敏感性、特异性和DOR的差异。荟萃分析纳入了12项观察性研究，包括PET/CT、MRI和CT单独或联合用于OSCC患者。基于US的单一研究数据不足以评估这种成像方式的价值。PET/CT的敏感性估计为0.87，MRI为0.70，CT为0.66。相应的合并特异性分别为0.79、0.79和0.81。PET/CT DOR分别为24.85、8.60、8.59。结论：与MRI和CT相比，PET/CT具有较好的诊断效果，可推荐用于临床检查OSCC患者的宫颈转移。
期刊介绍：
Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.
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