Advancements and potential in the prevention of congenital CMV infection

IF 2.9 3区医学 Q1 PEDIATRICS

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI:10.1016/j.siny.2025.101662

Yarlini Vipulanandan, Suresh Boppana, Karen B. Fowler, David W. Kimberlin

引用次数: 0

Abstract

Congenital cytomegalovirus (CMV) infection is a large contributor to neurodevelopmental delay and non-genetic sensorineural hearing loss, which can often be delayed in onset. While a majority of CMV infections are asymptomatic in healthy children and adults, periconceptual and early in utero infection can cause clinically significant and potentially long-term sequelae. The complex relationship between congenital CMV infection and maternal immunity provides a challenging backdrop for CMV prevention. Increased awareness of the significance of congenital CMV is reflected in the proliferation of prevention strategies over the past 30 years, including education initiatives, behavioral modifications, and maternal antiviral prophylaxis. This review explores different levels of congenital CMV prevention and highlights a variety of prevention strategies, including the potential for development of effective vaccines for CMV.

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预防先天性巨细胞病毒感染的进展和潜力。

先天性巨细胞病毒（CMV）感染是神经发育迟缓和非遗传性感音神经性听力损失的主要原因，通常可以延迟发病。虽然大多数巨细胞病毒感染在健康儿童和成人中是无症状的，但围孕期和子宫早期感染可引起临床显著的和潜在的长期后遗症。先天性巨细胞病毒感染与母体免疫之间的复杂关系为巨细胞病毒的预防提供了一个具有挑战性的背景。在过去的30年里，人们对先天性巨细胞病毒重要性的认识不断提高，这反映在预防策略的激增上，包括教育倡议、行为改变和孕产妇抗病毒预防。这篇综述探讨了先天性巨细胞病毒预防的不同层面，并强调了各种预防策略，包括开发有效的巨细胞病毒疫苗的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Fetal & Neonatal Medicine 医学-小儿科

CiteScore

6.40

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Fetal & Neonatal Medicine (formerly Seminars in Neonatology) is a bi-monthly journal which publishes topic-based issues, including current ''Hot Topics'' on the latest advances in fetal and neonatal medicine. The Journal is of interest to obstetricians and maternal-fetal medicine specialists. The Journal commissions review-based content covering current clinical opinion on the care and treatment of the pregnant patient and the neonate and draws on the necessary specialist knowledge, including that of the pediatric pulmonologist, the pediatric infectious disease specialist, the surgeon, as well as the general pediatrician and obstetrician. Each topic-based issue is edited by an authority in their field and contains 8-10 articles. Seminars in Fetal & Neonatal Medicine provides: • Coverage of major developments in neonatal care; • Value to practising neonatologists, consultant and trainee pediatricians, obstetricians, midwives and fetal medicine specialists wishing to extend their knowledge in this field; • Up-to-date information in an attractive and relevant format.