Meta-analysis of genetic diversity of VP1 gene of foot and mouth disease virus serotypes prevalent in Bangladesh from 2010 to 2024

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Infection Genetics and Evolution Pub Date : 2025-10-01 DOI:10.1016/j.meegid.2025.105835

Md. Abdur Rahman , Farah Zereen , Md. Al-Amin , Md. Golzar Hossain , Jahangir Alam , Masaru Shimada , Md. Tanvir Rahman , Sukumar Saha

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Abstract

Foot and Mouth Disease (FMD) is a transboundary viral disease caused by the Foot and Mouth Disease Virus (FMDV), which is classified into seven serotypes (A, O, C, Asia 1, SAT 1, SAT 2 and SAT 3) within the Picornaviridae family and Aphthovirus genus that affects both wild and domesticated cloven-hoofed animals, leading to high morbidity and substantial economic losses. In Bangladesh, three serotypes of FMDV: O, A, and Asia 1 predominantly affect cattle, remarkably more than one serotype in each year. Disease prevention relies on vaccination against the prevalent serotypes. However, despite extensive vaccination efforts, FMD outbreaks continue to occur due to high variability in FMDV, particularly of the VP1 gene, which gives rise to new variants and complicates control strategies. This review aims to Meta-analyze the epidemiological characteristics and functional divergence of prevalent FMDV serotypes in Bangladesh from 2010 to 2024 by examining their evolutionary history and dynamics based on partial VP1 gene sequences retrieved from NCBI GenBank database. It explores the FMDV serotypes, host, ecology, annual prevalence, sequence length, antigenic regions, evolutionary relationships, genotypes, and divergence, as well as amino acid variables in the BC loop, G-H loop and C-terminus region of the VP1 gene of prevalent FMDV serotypes. Additionally, the study addresses the similarity of currently used FMDV vaccine strains` VP1 amino acid sequences compare to VP1 amino acid sequence of prevalent FMDV serotypes, underscoring the need for updated vaccines that target circulating strains for effective disease control.

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2010 - 2024年孟加拉国流行口蹄疫病毒血清型VP1基因遗传多样性的meta分析

口蹄疫（FMD）是由口蹄疫病毒（FMDV）引起的一种跨界病毒性疾病，该病毒分为小核糖核酸病毒科和Aphthovirus属的七种血清型（a、O、C、Asia 1、SAT 1、SAT 2和SAT 3），可影响野生和家养的分蹄动物，导致高发病率和重大经济损失。在孟加拉国，三种血清型口蹄疫病毒：O型、A型和亚洲1型主要影响牛，每年明显不止一种血清型。疾病预防依赖于针对流行血清型的疫苗接种。然而，尽管开展了广泛的疫苗接种工作，但由于口蹄疫病毒，特别是VP1基因的高度变异，导致新的变异和控制策略复杂化，口蹄疫疫情继续发生。本文基于NCBI GenBank数据库检索的部分VP1基因序列，对2010 - 2024年孟加拉国流行FMDV血清型的进化历史和动态进行meta分析。探讨流行FMDV血清型、宿主、生态、年流行率、序列长度、抗原区、进化关系、基因型、分化，以及VP1基因BC环、G-H环和c端区的氨基酸变化。此外，该研究解决了目前使用的FMDV疫苗株的VP1氨基酸序列与流行的FMDV血清型的VP1氨基酸序列的相似性，强调需要更新针对流行菌株的疫苗以有效控制疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection Genetics and Evolution 医学-传染病学

CiteScore

8.40

自引率

0.00%

发文量

215

审稿时长

82 days

期刊介绍： (aka Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases -- MEEGID) Infectious diseases constitute one of the main challenges to medical science in the coming century. The impressive development of molecular megatechnologies and of bioinformatics have greatly increased our knowledge of the evolution, transmission and pathogenicity of infectious diseases. Research has shown that host susceptibility to many infectious diseases has a genetic basis. Furthermore, much is now known on the molecular epidemiology, evolution and virulence of pathogenic agents, as well as their resistance to drugs, vaccines, and antibiotics. Equally, research on the genetics of disease vectors has greatly improved our understanding of their systematics, has increased our capacity to identify target populations for control or intervention, and has provided detailed information on the mechanisms of insecticide resistance. However, the genetics and evolutionary biology of hosts, pathogens and vectors have tended to develop as three separate fields of research. This artificial compartmentalisation is of concern due to our growing appreciation of the strong co-evolutionary interactions among hosts, pathogens and vectors. Infection, Genetics and Evolution and its companion congress [MEEGID](http://www.meegidconference.com/) (for Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases) are the main forum acting for the cross-fertilization between evolutionary science and biomedical research on infectious diseases. Infection, Genetics and Evolution is the only journal that welcomes articles dealing with the genetics and evolutionary biology of hosts, pathogens and vectors, and coevolution processes among them in relation to infection and disease manifestation. All infectious models enter the scope of the journal, including pathogens of humans, animals and plants, either parasites, fungi, bacteria, viruses or prions. The journal welcomes articles dealing with genetics, population genetics, genomics, postgenomics, gene expression, evolutionary biology, population dynamics, mathematical modeling and bioinformatics. We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .