Respiratory-Related Leg Movement as a predictor of mortality: the Osteoporotic Fractures in Men (MrOS) sleep study.

IF 4.9 2区 医学 Q1 Medicine
Sleep Pub Date : 2025-10-04 DOI:10.1093/sleep/zsaf310
Neda Esmaeili, Sayaka Aritake, Susan Redline, John W Winkelman, Ali Azarbarzin
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引用次数: 0

Abstract

Study objectives: Respiratory event-related leg movements (RRLMs) in obstructive sleep apnea (OSA) may reflect event severity and predict adverse outcomes. This study examines the association between RRLM frequency and mortality.

Methods: A sample of 571 men (median [IQR] age: 76.0 [72.0-81.0] years; BMI: 28.0 [25.0-30.0] kg/m2) with an apnea-hypopnea index (AHI, ≥3% desaturation) ≥10 events/hour was selected based on available incident data and annotations of RRLMs, from the Osteoporotic Fractures in Men (MrOS) studies. RRLMs were scored if they occurred within ±5 seconds of respiratory event termination lasting 0.5-10 seconds; the average number of RRLMs per hour of sleep (RRLMI) was measured. For comparison, the number of periodic leg movements (PLMS) per hour of sleep (PLMI) was also quantified. Cox regression models estimated the adjusted hazard ratios (aHR) for mortality per SD increase in RRLMI and PLMI. Secondary analyses assessed the relationship between RRLM duration (i.e. a measure of RRLM strength) and measures of event severity (i.e. desaturation area, arousal, heart rate response, and event duration).

Results: There were 287 all-cause deaths during 11.4[6.9;12.5] years of follow-up. RRLMI and PLMI were 6.0[3.4;9.3] and 22.0[2.0;54.0] events/hour, respectively. In an adjusted model, every 1SD increase in RRLMI was associated with all-cause mortality (aHR:1.17[95% CI:1.01-1.34], p-value=0.03). In contrast, PLMI was not associated with mortality (aHR:1.04[95% CI:0.92-1.17], p-value=0.5). Furthermore, RRLM duration was linked to measures of event severity.

Conclusions: In a sample of older men with OSA, RRLMI was independently associated with all-cause mortality, whereas PLMI was not, though confirmatory studies are needed.

呼吸相关的腿部运动作为死亡率的预测因子:男性骨质疏松性骨折(mrs)睡眠研究。
研究目的:阻塞性睡眠呼吸暂停(OSA)患者呼吸事件相关腿部运动(RRLMs)可能反映事件严重程度并预测不良结局。本研究探讨RRLM频率与死亡率之间的关系。方法:根据现有事件数据和男性骨质疏松性骨折(mrs)研究中的rrlm注释,选择571名男性(中位[IQR]年龄:76.0[72.0-81.0]岁;BMI: 28.0 [25.0-30.0] kg/m2),呼吸暂停-低通气指数(AHI,≥3%去饱和)≥10事件/小时。如果RRLMs在呼吸事件终止后±5秒内发生,持续0.5-10秒,则进行评分;测量每小时睡眠中RRLMs的平均数量(RRLMI)。为了比较,每小时睡眠(PLMI)的周期性腿部运动(PLMS)次数也被量化。Cox回归模型估计了RRLMI和PLMI每SD增加的校正风险比(aHR)。二次分析评估了RRLM持续时间(即RRLM强度的测量)与事件严重程度的测量(即去饱和面积、觉醒、心率反应和事件持续时间)之间的关系。结果:随访11.4年[6.9;12.5]年,共有287例全因死亡。RRLMI为6.0[3.4;9.3],PLMI为22.0[2.0;54.0]次/h。在调整后的模型中,RRLMI每增加1SD与全因死亡率相关(aHR:1.17[95% CI:1.01-1.34], p值=0.03)。相比之下,PLMI与死亡率无关(aHR:1.04[95% CI:0.92-1.17], p值=0.5)。此外,RRLM持续时间与事件严重程度有关。结论:在患有OSA的老年男性样本中,RRLMI与全因死亡率独立相关,而PLMI与全因死亡率无关,尽管还需要进一步的确证研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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