{"title":"Entire corpus callosum and diffuse white matter involvement in acute Marchiafava-Bignami disease.","authors":"Jieqiang Xia, Qing Lin, Xue Ke","doi":"10.1007/s10072-025-08560-6","DOIUrl":null,"url":null,"abstract":"<p><p>Acute Marchiafava-Bignami disease (MBD) can extend beyond the corpus callosum to diffuse hemispheric white matter, portending poor outcomes. We report a 57-year-old man with long-standing alcohol abuse who developed weakness and coma. Magnetic resonance imaging (MRI) revealed hyperintense, swollen lesions throughout the corpus callosum and extracallosal white matter on T2-weighted imaging (T2WI)/fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging(DWI), consistent with cytotoxic edema. Despite prompt high-dose thiamine and aggressive supportive care, he died within days. This case underscores the diagnostic value of DWI for early detection and prognostication in acute MBD, and highlights the importance of urgent brain MRI in comatose patients with a background of chronic alcohol abuse.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10072-025-08560-6","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Acute Marchiafava-Bignami disease (MBD) can extend beyond the corpus callosum to diffuse hemispheric white matter, portending poor outcomes. We report a 57-year-old man with long-standing alcohol abuse who developed weakness and coma. Magnetic resonance imaging (MRI) revealed hyperintense, swollen lesions throughout the corpus callosum and extracallosal white matter on T2-weighted imaging (T2WI)/fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging(DWI), consistent with cytotoxic edema. Despite prompt high-dose thiamine and aggressive supportive care, he died within days. This case underscores the diagnostic value of DWI for early detection and prognostication in acute MBD, and highlights the importance of urgent brain MRI in comatose patients with a background of chronic alcohol abuse.
期刊介绍：
Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.
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