Hang Liu, Yandong Ma, Qian Chen, Yuting Dai, Yixuan Wang, Huating Huang, Zihan Yao, Chaoren Yan, Jingming Shi
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引用次数: 0
Abstract
Objectives: Inflammation, oxidative harm, and degradation of mitochondria ultimately contribute to the initiation neurodegenerative changes. This study investigated the inhibitory effects of rosavin and salidroside on neuroinflammation induced by β-amyloid oligomers using primary microglia derived from the cerebral tissue of C57BL/6 J mice.
Key findings: Following β-amyloid oligomers' production, a series of continuous neurological deterioration takes place. Rosavin and salidroside exhibited distinct inhibitory effects on different neurodegenerative damage. Subsequent studies indicated that the protective mechanism of rosavin was associated with nuclear factor к-B phosphorylation.
Lay summary: Rhodiola rosea L., with its natural small molecule compounds like rosavin may be potential candidates for the treatment of AD.
期刊介绍：
JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.
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