Validity and reliability of the Italian version of the Mild Behavioral Impairment Checklist in cognitively unimpaired and mild cognitive impairment individuals.

IF 3.1 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-10-03 DOI:10.1177/13872877251380299

Francesca Remelli, Federico Triolo, Giulia Grande, Maria Giorgia Barbieri, Elena Barbieri, Cristiana Galuppi, Giulia Pampolini, Stefano Volpato, Caterina Trevisan

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引用次数: 0

Abstract

BackgroundThe Mild Behavioral Impairment Checklist (MBI-C) is a tool for detecting MBI, a neurobehavioral syndrome associated with an increased dementia risk.ObjectiveThis study aimed to evaluate the reliability and validity of the Italian version of the informant-rated MBI-C in an outpatient sample of dementia-free individuals.MethodsA cross-sectional study was conducted on 72 older people without dementia (n = 47, mild cognitive impairment; n = 25, cognitively unimpaired). During the visit, physicians administrated the MBI-C and Neuropsychiatric Inventory Questionnaire (NPI-Q) to the informant. Internal consistency of MBI-C was measured by the Cronbach's coefficient alpha and inter-domain correlation coefficients. Diagnostic performance of MBI-C for clinically identified MBI by ISTAART criteria was assessed through ROC analysis, identifying the optimal cut-off based on the Youden Index. Spearman's correlations were used to evaluate the concurrent validity of MBI-C with the NPI-Q, Mini-Mental State Examination (MMSE), Instrumental Activity of Daily Living (IADL) and 3-item UCLA Loneliness Scale.ResultsMBI-C showed high internal consistency ( $α$ = 0.867) and strong inter-domain correlation ( $ρ$ = 0.760 $\sim$ 0.859, p < 0.001). The Area Under the Curve (AUC) for detecting clinical MBI was 0.937 (95%CI: 0.865-0.972), with an optimal cut-off of 5.5 (sensitivity = 0.849, specificity = 0.876). The MBI-C total score strongly correlated with the NPI-Q total score ( $ρ$ = 0.820, p < 0.001). Only the MBI-C total score significantly correlated with the 3-item UCLA ( $ρ$ = 0.236, p = 0.046); no significant correlations were found with MMSE and IADL scores.ConclusionsThe Italian version of MBI-C demonstrated strong reliability, validity, and diagnostic performance. Therefore, MBI-C may be a suitable tool for assessing behavioral symptoms in dementia-free individuals.

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意大利版轻度行为障碍检查表在认知正常和轻度认知障碍个体中的效度和信度。

轻度行为障碍检查表（MBI- c）是一种检测MBI的工具，MBI是一种与痴呆风险增加相关的神经行为综合征。目的：本研究旨在评估意大利版举报人评定的MBI-C在无痴呆患者门诊样本中的信度和效度。方法对72例无痴呆的老年人进行横断面研究（n = 47，轻度认知障碍；n = 25，认知未受损）。在访问期间，医生对被调查者进行了MBI-C和神经精神量表问卷（NPI-Q）。MBI-C的内部一致性通过Cronbach系数和域间相关系数来衡量。通过ROC分析评估MBI- c对ISTAART标准临床诊断为MBI的诊断效果，并根据约登指数确定最佳临界值。采用Spearman相关法评估MBI-C与NPI-Q、迷你精神状态检查（MMSE）、日常生活工具活动（IADL）和3项UCLA孤独量表的并发效度。结果smbi - c具有较高的内部一致性（α = 0.867）和较强的域间相关性（ρ = 0.760 ~ 0.859, p ρ = 0.820, p ρ = 0.236, p = 0.046）；与MMSE和IADL评分无显著相关性。结论意大利版MBI-C具有较强的信度、效度和诊断效能。因此，MBI-C可能是评估无痴呆个体行为症状的合适工具。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.