Trends in tuberculosis-related mortality among adults 35-85 years old in the United States, 1999 to 2022: a nationwide analysis.

IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM
Olivia Foley, Natalie Perme, Taylor Billion, Abubakar Tauseef, Renuga Vivekenandan
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引用次数: 0

Abstract

Background: Tuberculosis (TB) is a significant cause of mortality in the United States (US), impairing individual health and causing national financial burden. Although TB-related mortality has declined in recent years, a variety of factors still make TB difficult to prevent, necessitating further analysis of which demographic groups are most impacted by TB.

Methods: Trends in TB-related mortality in individuals aged 35 to 85 + years in the US from 1999 to 2022 were analyzed utilizing the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. Following data collection, age-adjusted mortality rate (AAMR) and average annual percent change (AAPC) in TB-related mortality were examined. Data was further stratified by sex, race, age, region, and locality.

Results: Between 1999 and 2022, there were 26,600 deaths related to TB in the US. Overall TB-related mortality significantly declined between 1999 and 2022 (AAPC, -3.95%). Males had consistently higher AAMR than females, with 16,741 deaths among males and 9,859 deaths among females. All racial groups, including Asian or Pacific Islander, Black or African American, White, and Hispanic or Latino individuals experienced significant declines in mortality (AAPC, -3.24%, -5.75%, -3.83%, -4.70%, respectively). Asian or Pacific Islander, Black or African American, and Hispanic or Latino patients had consistently higher AAMR than White patients between 1999 and 2022, however. Individuals older than 65 experienced significantly higher AAMR than younger individuals. South and West regions had higher AAMR than Northeast and Midwest regions, with the West and South experiencing the smallest and largest declines in mortality that were statistically significant, respectively (AAPC, -3.04%, -4.66%). TB-related mortality was higher in urban areas, with 20,680 deaths compared to 3,707 deaths in rural areas.

Conclusion: Although TB-related mortality has declined in the US overall, this improvement has not been experienced equally by all demographic groups.

1999年至2022年美国35-85岁成年人结核病相关死亡率趋势:一项全国性分析。
背景:结核病(TB)是美国(US)死亡的一个重要原因,损害个人健康并造成国家财政负担。尽管近年来结核病相关死亡率有所下降,但各种因素仍然使结核病难以预防,因此有必要进一步分析哪些人口群体受结核病影响最大。方法:利用疾病控制和预防中心广泛在线流行病学研究数据(CDC WONDER)数据库,分析1999年至2022年美国35至85岁以上人群结核病相关死亡率的趋势。收集数据后,检查年龄调整死亡率(AAMR)和结核病相关死亡率的平均年百分比变化(AAPC)。数据进一步按性别、种族、年龄、地区和地区分层。结果:1999年至2022年间,美国有26600人死于结核病。总体结核病相关死亡率在1999年至2022年间显著下降(AAPC, -3.95%)。男性AAMR始终高于女性,男性死亡人数为16,741人,女性死亡人数为9,859人。所有种族,包括亚洲或太平洋岛民、黑人或非裔美国人、白人、西班牙裔或拉丁裔个体的死亡率均显著下降(AAPC分别为-3.24%、-5.75%、-3.83%、-4.70%)。然而,在1999年至2022年期间,亚洲或太平洋岛民、黑人或非裔美国人、西班牙裔或拉丁裔患者的AAMR始终高于白人患者。65岁以上的人的AAMR明显高于年轻人。南部和西部地区的AAMR高于东北部和中西部地区,西部和南部分别经历了最小和最大的死亡率下降,具有统计学意义(AAPC, -3.04%, -4.66%)。与结核病有关的死亡率在城市地区较高,有20 680人死亡,而农村地区有3 707人死亡。结论:尽管美国结核病相关死亡率总体上有所下降,但并非所有人口群体都有同样的改善。
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来源期刊
BMC Pulmonary Medicine
BMC Pulmonary Medicine RESPIRATORY SYSTEM-
CiteScore
4.40
自引率
3.20%
发文量
423
审稿时长
6-12 weeks
期刊介绍: BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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