Decreased voxel-mirrored homotopic connectivity in adolescent major depressive disorder with suicidal ideation.

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-10-01 DOI:10.1016/j.bbr.2025.115852

Mingmeng Huang, Qinyao Sun, Lin Ma, Jing Tian, Menghan Gao, Yuting Jiang, Yijia Zhou, Zixuan Cheng, Jingwen Liu, Yu Zhang, Yuanchao Zhang, Liangbo Hu

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引用次数: 0

Abstract

Objective: Although altered brain activity is associated with suicidal ideation (SI) in adolescents with major depressive disorder (MDD), the status of inter-hemispheric connectivity remains elusive. This study aimed to investigate changes in resting-state interhemispheric functional connectivity in adolescents with MDD and SI.

Methods: A total of 45 adolescents with MDD and SI and 28 healthy controls (HCs) underwent comprehensive psychological assessments and MRI scans. Voxel-mirrored homotopic connectivity (VMHC) was compared between the two groups. We also performed correlation analyses between VMHC values of the affected brain regions and clinical characteristics.

Results: Compared to HCs, adolescents with MDD and SI showed decreased VMHC values in the bilateral angular gyri, bilateral insulae, bilateral middle occipital cortices, bilateral cerebellar regions and the right precuneus. No significant correlation was found between the VMHC values of affected brain regions and the clinical data in the adolescents with MDD and SI.

Conclusion: This study demonstrates decreased inter-hemispheric functional connectivity in multiple brain regions among adolescents with MDD and SI, suggesting potential disruptions in neural coordination between hemispheres. These results provide novel insights into the neurobiological mechanisms underlying SI in MDD, highlighting the potential role of impaired hemispheric integration in its pathophysiology.

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青少年重度抑郁症伴自杀意念的体素镜像同位连通性降低。

目的：虽然大脑活动的改变与青少年重度抑郁症（MDD）的自杀意念（SI）有关，但大脑半球间连通性的状态仍然难以捉摸。本研究旨在探讨MDD和SI青少年静息状态下半球间功能连接的变化。方法：对45名MDD和SI青少年和28名健康对照（hc）进行了全面的心理评估和MRI扫描。比较两组体素镜像同伦连通性（VMHC）。我们还分析了受累脑区的VMHC值与临床特征之间的相关性。结果：与hc相比，MDD和SI的青少年双侧角回、双侧岛叶、双侧枕中皮质、双侧小脑区和右侧楔前叶的VMHC值均降低。MDD和SI青少年患区的VMHC值与临床资料无显著相关性。结论：本研究表明，患有重度抑郁症和孤独症的青少年大脑多个区域的功能连通性下降，表明大脑半球之间的神经协调可能受到破坏。这些结果为MDD中SI的神经生物学机制提供了新的见解，强调了半球整合受损在其病理生理中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.