Reduced harmonic complexity of brain parenchymal cardiovascular pulse waveforms in Alzheimer’s disease

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-10-01 DOI:10.1016/j.neuroimage.2025.121503

Anssi Koivula , Vilma Perkiömäki , Mika Aho , Aleksi Rasila , Valter Poltojainen , Vesa Korhonen , Matti Järvelä , Niko Huotari , Heta Helakari , Johanna Tuunanen , Lauri Raitamaa , Tommi Väyrynen , Johanna Kruger , Vesa Kiviniemi , Janne Kananen

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引用次数: 0

Abstract

Alzheimer’s disease (AD) is characterized by specific neuropathologies, and is associated with arterial wall β-amyloid accumulations, which lead to radiologically detectable amplitude increases and variable propagation speed of cardiovascular impulses in brain. In this study, we developed a fast frequency domain imaging method know as relative harmonic power of magnetic resonance encephalography (MREG_RHP), aiming to investigate the configuration of the cardiovascular impulses independently of the mean magnetic resonance signal intensity and physiological impulse amplitude. In the initial analyses in healthy controls, we found that a wide 0.8 - 5 Hz bandpass produced the most physiologically realistic cardiovascular waveforms. Whereas the data recorded in cerebrospinal fluid (CSF) with flip angle (FA) of 25° yielded up to 7-fold higher cardiac signal intensity as compared to FA of 5°, within the brain tissue recordings with FA of 5° were markedly more sensitive to cardiac waveform. We detected arterial impulses originating from major arteries and extending into the surrounding brain parenchyma, with simultaneous dampening of amplitude as a function of distance from source. Finally, we compared MREG_RHP results in 34 CE patients (mean age: 60.7 ± 4.7 years; 53 % female) against 29 controls (mean age: 56.9 ± 7.9 years; 66 % female). We show that the harmonic power of cardiovascular brain pulses is significantly reduced in cortical frontoparietal areas of AD patients, indicating monotonous impulse patterns colocalizing with the previously reported areas of increased impulse propagation speed. In conclusion, the MREG_RHP offers a fast Fourier transform (FFT)-based method to non-invasively quantify and locate human arterial blood vessel wall pathology.

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降低阿尔茨海默病脑实质心血管脉冲波形的谐波复杂性

阿尔茨海默病（AD）以特定的神经病变为特征，与动脉壁β-淀粉样蛋白积累有关，导致放射学可检测到的脑内心血管脉冲振幅增加和传播速度变化。在这项研究中，我们开发了一种快速频域成像方法，即磁共振脑电图的相对谐波功率（MREGRHP），旨在研究独立于磁共振平均信号强度和生理脉冲幅值的心血管脉冲的配置。在对健康对照的初步分析中，我们发现0.8 - 5hz宽带通产生的心血管波形在生理上最真实。而在脑脊液（CSF）中记录的数据，当翻转角（FA）为25°时，产生的心脏信号强度比翻转角为5°时高7倍，而在脑组织中，翻转角为5°的记录对心脏波形明显更敏感。我们检测到来自大动脉的动脉脉冲，并延伸到周围的脑实质，同时振幅随着距离源的距离而减弱。最后，我们比较了34例CE患者（平均年龄：60.7±4.7岁，53%为女性）和29例对照组（平均年龄：56.9±7.9岁，66%为女性）的MREGRHP结果。我们发现，AD患者大脑皮层额顶叶区心血管脑脉冲的谐波功率显著降低，表明单调的脉冲模式与先前报道的脉冲传播速度增加的区域共定位。总之，MREGRHP提供了一种快速的基于傅里叶变换（FFT）的方法来无创地量化和定位人体动脉血管壁病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.