A high-performance BaTiO3/Ag/BP-based plasmonic biosensor for label-free detection of cancer biomarkers

IF 4.9 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Sensors and Actuators A-physical Pub Date : 2025-09-30 DOI:10.1016/j.sna.2025.117121

Arnab Saha, Md Tawabur Rahman, Biswajit Dey

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引用次数: 0

Abstract

Cancer remains a major global health challenge, emphasizing the need for early and accurate detection to improve treatment outcomes and survival rates. Surface plasmon resonance (SPR) biosensors have gained popularity as advanced diagnostic tools, offering label-free and real-time detection with high sensitivity to changes in the refractive index (RI) of biological specimens. In this work, we propose a multilayer SPR biosensor based on a BK₇/BaTiO₃/Ag/black phosphorus (BP) structure, designed using the Kretschmann configuration to enhance performance and biocompatibility. The optical response of the biosensor was first evaluated using the Transfer Matrix Method (TMM) and subsequently compared to Finite-Difference Time-Domain (FDTD) simulations to ensure accuracy and reliability. Optimization results showed that a structure comprising 35 nm of BaTiO₃, 50 nm of Ag, and five BP layers delivers enhanced sensing performance. In practical applications, the biosensor successfully distinguished various cancer cell types based on their unique RI values, with a peak sensitivity of 417.86°/RIU for MCF-7 cells (breast cancer type II). Additionally, the biosensor reached a peak QF of 109.29 RIU⁻¹ and a DA of 2.33, confirming reliable performance. With its strong linearity across a broad RI range (1.335–1.405) and compatibility with standard fabrication techniques, the proposed biosensor offers a scalable, non-invasive solution for early-stage cancer diagnostics and high-throughput clinical screening.

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基于BaTiO3/Ag/ bp的高性能等离子体生物传感器，用于无标记检测癌症生物标志物

癌症仍然是一项重大的全球卫生挑战，强调需要进行早期和准确的检测，以改善治疗结果和生存率。表面等离子体共振（SPR）生物传感器作为一种先进的诊断工具，对生物标本的折射率（RI）变化提供无标签和高灵敏度的实时检测，已经得到了广泛的应用。在这项工作中，我们提出了一种基于BK7/BaTiO3/Ag/黑磷（BP）结构的多层SPR生物传感器，采用Kretschmann构型设计以提高性能和生物相容性。生物传感器的光学响应首先使用传递矩阵法（TMM）进行评估，随后与时域有限差分（FDTD）模拟进行比较，以确保准确性和可靠性。优化结果表明，由35 nm的BaTiO3, 50 nm的Ag和5个BP层组成的结构具有增强的传感性能。在实际应用中，该生物传感器根据其独特的RI值成功区分了不同类型的癌细胞，MCF-7细胞（乳腺癌II型）的峰值灵敏度为417.86°/RIU。此外，该生物传感器的峰值QF为109.29 RIU−1，DA为2.33，证实了其可靠的性能。由于其在广泛的RI范围内（1.335-1.405）具有很强的线性，并且与标准制造技术兼容，所提出的生物传感器为早期癌症诊断和高通量临床筛查提供了可扩展的非侵入性解决方案。

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来源期刊

Sensors and Actuators A-physical 工程技术-工程：电子与电气

CiteScore

8.10

自引率

6.50%

发文量

630

审稿时长

49 days

期刊介绍： Sensors and Actuators A: Physical brings together multidisciplinary interests in one journal entirely devoted to disseminating information on all aspects of research and development of solid-state devices for transducing physical signals. Sensors and Actuators A: Physical regularly publishes original papers, letters to the Editors and from time to time invited review articles within the following device areas: • Fundamentals and Physics, such as: classification of effects, physical effects, measurement theory, modelling of sensors, measurement standards, measurement errors, units and constants, time and frequency measurement. Modeling papers should bring new modeling techniques to the field and be supported by experimental results. • Materials and their Processing, such as: piezoelectric materials, polymers, metal oxides, III-V and II-VI semiconductors, thick and thin films, optical glass fibres, amorphous, polycrystalline and monocrystalline silicon. • Optoelectronic sensors, such as: photovoltaic diodes, photoconductors, photodiodes, phototransistors, positron-sensitive photodetectors, optoisolators, photodiode arrays, charge-coupled devices, light-emitting diodes, injection lasers and liquid-crystal displays. • Mechanical sensors, such as: metallic, thin-film and semiconductor strain gauges, diffused silicon pressure sensors, silicon accelerometers, solid-state displacement transducers, piezo junction devices, piezoelectric field-effect transducers (PiFETs), tunnel-diode strain sensors, surface acoustic wave devices, silicon micromechanical switches, solid-state flow meters and electronic flow controllers. Etc...