Somatic symptom disorder in patients with irritable bowel syndrome or ulcerative colitis – Cross-sectional baseline findings from the SOMA.GUT-RCT

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-09-24 DOI:10.1016/j.jpsychores.2025.112395

Luisa Peters , Anna Matysiak , Sina Hübener , Ansgar W. Lohse , Yvonne Nestoriuc , Kerstin Maehder , Bernd Löwe

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引用次数: 0

Abstract

Background

Somatic symptom disorder (SSD) is characterised by distressing somatic symptoms accompanied by excessive symptom-related thoughts, emotions, or behaviour. While initial evidence supports SSD's relevance in gastrointestinal conditions like irritable bowel syndrome (IBS) and ulcerative colitis (UC), structured interview-based data are lacking. This study examined SSD frequency and its associations with biopsychosocial variables in patients with IBS or UC recruited in the context of a psychological intervention trial.

Methods

Cross-sectional baseline data from a randomised controlled trial of patients with UC or IBS were analysed. SSD was diagnosed using structured DSM-5-based diagnostic interviews. Measures included illness-related anxiety (WI-7), neuroticism (BFI-10), illness perceptions (B-IPQ), symptom-related disability (adapted PDI), and gastrointestinal symptom severity (IBS-SSS). Between-group comparisons and multiple logistic regression analysis were conducted.

Results

SSD was diagnosed in 41.5 % (95 % CI 35.6–47.9) out of 236 patients, including 125 patients with UC and 111 with IBS (73.7 % female; M_age = 40.14, SD = 13.8). SSD was more frequent in IBS (55.0 %; 95 % CI 44.4–64.9) than in UC (29.6 %; 95 % CI 21.7–37.1) (χ²(1) = 15.67, p < .001), and linked to higher illness-related anxiety, negative illness perceptions, and symptom-related disability in both groups. Gastrointestinal symptom severity was highest in patients with IBS and SSD. Regression analysis showed IBS diagnosis, illness-related anxiety, and neuroticism correlated with SSD.

Conclusions

A substantial number of patients with IBS or UC met SSD criteria in structured interviews. SSD occurred more commonly in IBS and was associated with psychological distress in both conditions. Findings highlight SSD's diagnostic relevance in functional and inflammatory bowel diseases. Future studies should investigate whether targeted SSD diagnosis and treatment in these conditions could improve clinical outcomes.

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肠易激综合征或溃疡性结肠炎患者的躯体症状障碍——来自SOMA的横断面基线结果GUT-RCT

躯体症状障碍（SSD）的特征是令人痛苦的躯体症状伴随着过多的与症状相关的思想、情绪或行为。虽然最初的证据支持固态硬盘与肠易激综合征（IBS）和溃疡性结肠炎（UC）等胃肠道疾病的相关性，但缺乏结构化的基于访谈的数据。本研究调查了在心理干预试验背景下招募的IBS或UC患者的SSD频率及其与生物心理社会变量的关系。方法分析UC或IBS患者随机对照试验的横断面基线数据。SSD的诊断采用结构化的基于dsm -5的诊断访谈。测量包括疾病相关焦虑（WI-7）、神经质（BFI-10）、疾病感知（B-IPQ）、症状相关残疾（适应性PDI）和胃肠道症状严重程度（IBS-SSS）。进行组间比较和多元logistic回归分析。结果236例患者中有41.5% （95% CI 35.6-47.9）诊断为sssd，其中UC 125例，IBS 111例（女性73.7%,Mage = 40.14, SD = 13.8）。SSD在IBS中的发生率（55.0%;95% CI 44.4-64.9）高于UC (29.6%; 95% CI 21.7-37.1) (χ2(1) = 15.67, p < .001)，并且在两组中均与较高的疾病相关焦虑、负面疾病感知和症状相关残疾相关。肠易激综合征和SSD患者的胃肠道症状严重程度最高。回归分析显示IBS诊断、疾病相关焦虑和神经质与SSD相关。结论：在结构化访谈中，大量IBS或UC患者符合SSD标准。SSD在IBS中更常见，并且在两种情况下都与心理困扰有关。研究结果强调SSD在功能性和炎症性肠病中的诊断相关性。未来的研究应该调查在这些情况下有针对性的SSD诊断和治疗是否可以改善临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.