A biomimetic approach to skin-targeted drug delivery: A perspective on mesoporous silica–polysaccharide hybrids for regenerative cosmeceuticals

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-23 DOI:10.1016/j.bioadv.2025.214524

Noor Ul Ain , Bilqees Hussain , Qura tul Ain , Muhammad Ramzan , Bibimaryam Khan , Farid Menaa

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Abstract

Skin disorders such as acne and photoaging arise from intersecting biological processes including microbial imbalance, chronic inflammation, oxidative stress, and extracellular matrix degradation. Conventional therapies often provide partial or short-term relief while carrying risks of irritation or resistance. A promising alternative lies in biomimetic systems that integrate mesoporous silica nanoparticles (MSNs) with herbal polysaccharides. MSNs offer structural tunability, high loading capacity, and controlled release, while polysaccharides contribute intrinsic antioxidant, anti-inflammatory, antimicrobial, and regenerative properties. When combined, these hybrids function as adaptive carriers and bioactive agents, capable of reinforcing skin repair and hydration while attenuating pathological signaling. By aligning nanostructured design with natural bioactivity, MSN–polysaccharide systems represent a forward-looking strategy for regenerative cosmeceuticals, bridging traditional therapeutics and precision nanotechnology.

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皮肤靶向药物递送的仿生方法：用于再生药妆的介孔硅-多糖混合物的前景

痤疮和光老化等皮肤疾病是由交叉的生物过程引起的，包括微生物失衡、慢性炎症、氧化应激和细胞外基质降解。传统疗法通常提供部分或短期缓解，但有刺激或抵抗的风险。将介孔二氧化硅纳米颗粒（MSNs）与草药多糖结合的仿生系统是一种很有前途的替代方案。msn具有结构可调性、高负载能力和控释性，而多糖具有固有的抗氧化、抗炎、抗菌和再生特性。当结合时，这些杂交种作为适应性载体和生物活性剂，能够加强皮肤修复和水合作用，同时减弱病理信号。通过将纳米结构设计与天然生物活性相结合，msn -多糖系统代表了再生药妆的前瞻性策略，将传统治疗和精密纳米技术连接起来。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!